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pH변화가 심실근 경축현상에 미치는 영향
Effect of Extracellular pH on Contracture in Frog Ventricle

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Authors
김전; 박준; 박영배
Issue Date
1983-06
Publisher
서울대학교 의과대학
Citation
Seoul J Med, Vol.24 No.2, pp. 175-184
Abstract
Potassium contractures were induced in isolated
frog(Rana tcmporaria) ventricular strips with trisbuffered
Ringer solutions containing 20~100mM K
ions and concomitantly less Na ions at room temperaturet
lS to 20nC). External pH was raised up to
8.4 or lowered down to 6.4 and its effect upon
K-contracture was investigated to elicit the mechanism
of action of H ions on excitation-contraction
coupling in frog ventricular myocardium.
Followings are the results obtained:
]. At normal pH, biphasic contracture was evoked
at external K concentration of 40mM. On rasing
K concentration to lOOmM, contracture tension
increased gradually and the interval between the
end of contracture and resuming of twitch was also
prolonged. When K-20mM solution was replaced by
normal Ringer solution, twitch tension developed
rapidly and much higher tension than control twitch
was elicited transiently. After the first application
of K-100mM fully recovered tensions were always
smaller than those of control twitch tensions.
2. On raising external pH from normal to 8.4,
there were no significant changes in K-induced contractures
comparing to those evoked under normal
pH.
3. On lowering external pH down to 7.4, phasic
portion of K-contractures were augmented within
the range of 20 to 40mM K and tonic portions in
creased gradually with time elapsed at 100mM K
ion concentrations.
From the above results it was concluded that H
ion acted upon contracture induced by high K with low
Na ion" Via the inhibition of Na-K pump during
the early phase and changes in intracellular pII
during the later phase.
ISSN
0582-6802
Language
Korean
URI
https://hdl.handle.net/10371/6813
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 24 No.2 (1983)
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