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New antiepileptic drugs in pediatric epilepsy

Cited 31 time in Web of Science Cited 32 time in Scopus
Authors
Hwang, Hee; Kim, Ki Joong
Issue Date
2008-03-11
Publisher
Elsevier
Citation
Brain Dev. 2008;30(9):549-555
Keywords
Amines/adverse effects/pharmacokinetics/therapeutic useAnticonvulsants/adverse effects/pharmacokinetics/*therapeutic useCarbamazepine/adverse effects/analogs & derivatives/pharmacokinetics/therapeutic useChildChild, PreschoolCyclohexanecarboxylic Acids/adverse effects/pharmacokinetics/therapeutic useEpilepsy/*drug therapyFructose/adverse effects/analogs & derivatives/pharmacokinetics/therapeutic useHumansPediatricsPhenylcarbamates/adverse effects/pharmacokinetics/therapeutic usePiracetam/adverse effects/analogs & derivatives/pharmacokinetics/therapeutic usePractice Guidelines as TopicPropylene Glycols/adverse effects/pharmacokinetics/therapeutic useTriazines/adverse effects/pharmacokinetics/therapeutic useVigabatrin/adverse effects/pharmacokinetics/therapeutic usegamma-Aminobutyric Acid/adverse effects/pharmacokinetics/therapeutic use
Abstract
New antiepileptic drugs (AEDs), introduced since 1993, provide more diverse options in the treatment of epilepsy. Despite the equivalent efficacy and better tolerability of these drugs, more than 25% of patients remain refractory to treatment. Moreover, the issues for pediatric patients are different from those for adults, and have not been addressed in the development and application of the new AEDs. Recently published evidence-based treatment guidelines have helped physicians to choose the most reasonable AED, although they cannot fully endorse new AEDs because of the lack of well-designed, randomized controlled trials. We review the mechanisms of action, pharmacokinetic properties, adverse reactions, efficacy, and tolerability of eight new AEDs (felbamate, gabapentin, lamotrigine, levetiracetam, oxcarbazepine, topiramate, vigabatrin, and zonisamide), focusing on currently available treatment guidelines and expert opinions regarding pediatric epilepsy.
ISSN
0387-7604 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18328657

http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T50-4S0HBYV-1-1&_cdi=4988&_user=168665&_orig=search&_coverDate=10%2F31%2F2008&_sk=999699990&view=c&wchp=dGLzVtb-zSkzk&md5=3a9fabc0092b4235f825e38a818877e8&ie=/sdarticle.pdf

https://hdl.handle.net/10371/68130
DOI
https://doi.org/10.1016/j.braindev.2008.01.007
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College of Medicine/School of Medicine (의과대학/대학원)Pediatrics (소아과학전공)Journal Papers (저널논문_소아과학전공)
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