S-Space College of Medicine/School of Medicine (의과대학/대학원) Pediatrics (소아과학전공) Journal Papers (저널논문_소아과학전공)
New antiepileptic drugs in pediatric epilepsy
- Hwang, Hee; Kim, Ki Joong
- Issue Date
- Brain Dev. 2008;30(9):549-555
- Amines/adverse effects/pharmacokinetics/therapeutic use; Anticonvulsants/adverse effects/pharmacokinetics/*therapeutic use; Carbamazepine/adverse effects/analogs & derivatives/pharmacokinetics/therapeutic use; Child; Child, Preschool; Cyclohexanecarboxylic Acids/adverse effects/pharmacokinetics/therapeutic use; Epilepsy/*drug therapy; Fructose/adverse effects/analogs & derivatives/pharmacokinetics/therapeutic use; Humans; Pediatrics; Phenylcarbamates/adverse effects/pharmacokinetics/therapeutic use; Piracetam/adverse effects/analogs & derivatives/pharmacokinetics/therapeutic use; Practice Guidelines as Topic; Propylene Glycols/adverse effects/pharmacokinetics/therapeutic use; Triazines/adverse effects/pharmacokinetics/therapeutic use; Vigabatrin/adverse effects/pharmacokinetics/therapeutic use; gamma-Aminobutyric Acid/adverse effects/pharmacokinetics/therapeutic use
- New antiepileptic drugs (AEDs), introduced since 1993, provide more diverse options in the treatment of epilepsy. Despite the equivalent efficacy and better tolerability of these drugs, more than 25% of patients remain refractory to treatment. Moreover, the issues for pediatric patients are different from those for adults, and have not been addressed in the development and application of the new AEDs. Recently published evidence-based treatment guidelines have helped physicians to choose the most reasonable AED, although they cannot fully endorse new AEDs because of the lack of well-designed, randomized controlled trials. We review the mechanisms of action, pharmacokinetic properties, adverse reactions, efficacy, and tolerability of eight new AEDs (felbamate, gabapentin, lamotrigine, levetiracetam, oxcarbazepine, topiramate, vigabatrin, and zonisamide), focusing on currently available treatment guidelines and expert opinions regarding pediatric epilepsy.
- 0387-7604 (Print)
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