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Menthol regulates TRPM8-independent processes in PC-3 prostate cancer cells

Cited 36 time in Web of Science Cited 47 time in Scopus
Authors
Kim, Su-Hwa; Nam, Joo-Hyun; Park, Eun-Jung; Kim, Byung-Joo; Kim, Sung-Joon; So, Insuk; Jeon, Ju-Hong
Issue Date
2009
Publisher
Elsevier
Citation
Biochim Biophys Acta. 1792 (2009) 33-38
Keywords
Calcium/metabolismCalcium Channels/metabolismCell Death/drug effects/physiologyCell Line, TumorHumansIon Transport/drug effectsJNK Mitogen-Activated Protein Kinases/metabolismMaleMenthol/*pharmacologyNerve Tissue Proteins/metabolismProstatic Neoplasms/*drug therapy/genetics/*metabolism/pathologySignal Transduction/drug effectsTRPM Cation Channels/genetics/*metabolismTransient Receptor Potential Channels/metabolism
Abstract
Menthol, a naturally occurring compound from peppermint oil, binds and activates the TRPM8 Ca(2+)-permeable channel that exhibits abnormal expression patterns in prostate cancer, suggesting that TRPM8 links Ca(2+) transport pathways to tumor biology. We thus investigated the cellular responses of prostate cancer cells to menthol. Here we found that menthol increases [Ca(2+)](i) via Ca(2+) influx mechanism(s) independent of TRPM8 in PC-3 cells. We demonstrated that menthol induces cell death at supramillimolar concentrations in PC-3 cells and the cell death is not suppressed by low extracellular Ca(2+) condition which indicates that menthol-induced cell death is not associated with Ca(2+) influx pathways. In addition, we showed that menthol increases a phosphorylated form of c-jun N-terminal kinase (JNK) in PC-3 cells through TRPM8-independent mechanisms. Thus, our data indicate that there is an apparent lack of causality between TRPM8 activation and menthol-induced cell death and that menthol can regulate TRPM8-independent Ca(2+)-transport and cellular processes.
ISSN
0006-3002 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18955132

http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T1Y-4TMSNST-1-H&_cdi=4903&_user=168665&_orig=search&_coverDate=01%2F31%2F2009&_sk=982079998&view=c&wchp=dGLbVzW-zSkWA&md5=022f103d6171c4e9c6184bea83ed7ae9&ie=/sdarticle.pdf

http://hdl.handle.net/10371/68147
DOI
https://doi.org/10.1016/j.bbadis.2008.09.012
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Physiology (생리학교실)Journal Papers (저널논문_생리학교실)
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