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Dermal fibrosis in male pattern hair loss: a suggestive implication of mast cells

Cited 11 time in Web of Science Cited 11 time in Scopus
Authors
Won, Chong Hyun; Kwon, Oh Sang; Kim, Yeon Kyung; Kang, Yong Jung; Kim, Beom Joon; Choi, Chong Won; Eun, Hee Chul; Cho, Kwang Hyun
Issue Date
2008-02-21
Publisher
Springer Verlag
Citation
Arch Dermatol Res. 300(3):147-152
Keywords
AdultAlopecia/metabolism/*pathologyCase-Control StudiesCell CountChymases/metabolismCollagen/metabolismElastic Tissue/metabolism/pathologyFibrosisHumansMaleMast Cells/metabolism/*pathologyTryptases/metabolism
Abstract
A relationship has been suggested between mast cells (MCs) and male pattern hair loss (MPHL), because of histological evidence of perifollicular fibrosis and increased mast cell numbers. Two paired punch biopsies were taken from balding vertexes and non-balding occipital promontory areas of ten patients with MPHL (Ludwig-Hamilton IIIv to IV) and from five normal subjects aged from 20 to 35 years. Masson trichrome and Victoria blue staining were performed to observe collagen frameworks and elastic fiber structures. Numbers of immunoreactive MCs stained with anti-tryptase or anti-chymase antibody were counted. It was found that collagen bundles were significantly increased in balding vertexes than in non-balding occiput scalp skin. A near 4-fold increase in elastic fibers was observed in both vertex and occiput scalp skins with MPHL versus controls. Total numbers of MCs (tryptase-positive) in site-matched scalp samples were about 2-fold higher in MPHL subjects than in normal controls. Percentage elastic fiber (%) was found to be relatively well-correlated with tryptase and chymase-positive MCs. These findings suggest that accumulated MCs might be responsible for increased elastic fiber synthesis in MPHL, and indicate that future investigations are warranted.
ISSN
0340-3696 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18286292

http://www.springerlink.com/content/50j32n1157433117/fulltext.pdf

http://hdl.handle.net/10371/68158
DOI
https://doi.org/10.1007/s00403-007-0826-x
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College of Medicine/School of Medicine (의과대학/대학원)Dermatology (피부과학전공)Journal Papers (저널논문_피부과학전공)
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