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Neuro-Behcet's disease mimicking multiple brain tumors: diffusion-weighted MR study and literature review

Cited 19 time in Web of Science Cited 20 time in Scopus
Authors
Heo, Jae-Hyeok; Lee, Soon-Tae; Chu, Kon; Kim, Manho
Issue Date
2007-09-14
Publisher
Elsevier
Citation
J Neurol Sci. 2008;264(1-2):177-181
Keywords
Anti-Bacterial Agents/therapeutic useBehcet Syndrome/*diagnosis/physiopathologyBrain/*pathology/physiopathologyBrain Neoplasms/*diagnosis/physiopathologyDiagnosis, DifferentialDiagnostic Errors/prevention & controlDiffusion Magnetic Resonance ImagingGliosis/etiology/pathologyHumansLymphocytes/pathologyMaleMiddle AgedNecrosis/etiology/pathologyParietal Lobe/pathologyPons/pathologySteroids/therapeutic useTreatment Outcome
Abstract
A 47-year-old man with Behcet's disease presented with a five day history of right side weakness and dysarthria. Ten years ago, he was diagnosed as Behcet's disease. Since then, he was treated with low dose steroids. T1-weighted magnetic resonance images with gadolinium injection revealed ring enhancing lesions with internal hypointensities at the left side of the pons and at the left parietal cortex suggesting multiple metastatic tumors. Diffusion-weighted image and ADC map revealed central hyperintensity on diffusion with low ADC values at both lesions. The histopathology of stereotactic biopsy specimen showed frequent perivascular lymphocytic cuffings, focal necrotic lesions and reactive gliosis. The most common neuropathologic findings in neuro-Behcet's disease are focal necrotic lesions, but the location in cerebral cortex has not been reported before. Long term steroid therapy and antibiotics were administered and the patient recovered gradually. Neuro-Behcet's disease could be presented as brain tumor like lesion, and stereotactic biopsy should be considered in such situation.
ISSN
0022-510X (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17850821

http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T06-4PMYXX8-1-9&_cdi=4854&_user=168665&_orig=search&_coverDate=01%2F15%2F2008&_sk=997359998&view=c&wchp=dGLbVzz-zSkzS&md5=e89816f20b37d709c88a4569963c5b44&ie=/sdarticle.pdf

http://hdl.handle.net/10371/68162
DOI
https://doi.org/10.1016/j.jns.2007.07.029
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Neurology (신경과학교실)Journal Papers (저널논문_신경과학교실)
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