항경제의 혈중농도와 부작용에 관한 연구 II

Abstract

Diphenylhydantoin was given without combination of other anticonvulsants to 85 male and 51 female epileptic patients of different age groups. All investigated patients were free from seizure during the study period of a half year. Each patients were investigated clinically and checked serum concentration of the drug more than I times in that period. We have used EMIT system by determination of the serum concentration of the drug. We have found that the tendencies to took more drugs to maintaining the optimal therapeutic serum concentrations as younger the age groups of patients. The patients under the age of 9 needs 10~17mg/kg to maintainc the optimal serum concentration just below 20.0I'g/ml. This tendenccs was remarkable under the age of 15 years. Age groups above 15 years, there are no differences of the optimal daily dosage compared with adult groups. They need 4~7 mg/kg of drugs to obtain the optimal serum concentrations. Appearance of the side effects began as low serum concentration as 13.5I'g/ml with the symptom of diplopia. The frequencies of the appearence of the side effects increase there after as the serum cone. increases. These increases rapidly as the serum concentrations are above 30.0I'g/ml, while below this level randomel y appears. The related literature were reviewed in detail.