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Glutathione peroxidase 3 mediates the antioxidant effect of peroxisome proliferator-activated receptor gamma in human skeletal muscle cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chung, Sung Soo | - |
dc.contributor.author | Kim, Min | - |
dc.contributor.author | Youn, Byoung-Soo | - |
dc.contributor.author | Lee, Nam Seok | - |
dc.contributor.author | Park, Ji Woo | - |
dc.contributor.author | Lee, In Kyu | - |
dc.contributor.author | Lee, Yun Sok | - |
dc.contributor.author | Kim, Jae Bum | - |
dc.contributor.author | Cho, Young Min | - |
dc.contributor.author | Lee, Hong Kyu | - |
dc.contributor.author | Park, Kyong Soo | - |
dc.date.accessioned | 2010-07-01T23:26:16Z | - |
dc.date.available | 2010-07-01T23:26:16Z | - |
dc.date.issued | 2008-10-22 | - |
dc.identifier.citation | Mol Cell Biol. 29(1):20-30 | en |
dc.identifier.issn | 1098-5549 (Electronic) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18936159 | - |
dc.identifier.uri | http://mcb.asm.org/cgi/reprint/29/1/20.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/68182 | - |
dc.description.abstract | Oxidative stress plays an important role in the pathogenesis of insulin resistance and type 2 diabetes mellitus and in diabetic vascular complications. Thiazolidinediones (TZDs), a class of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists, improve insulin sensitivity and are currently used for the treatment of type 2 diabetes mellitus. Here, we show that TZD prevents oxidative stress-induced insulin resistance in human skeletal muscle cells, as indicated by the increase in insulin-stimulated glucose uptake and insulin signaling. Importantly, TZD-mediated activation of PPARgamma induces gene expression of glutathione peroxidase 3 (GPx3), which reduces extracellular H(2)O(2) levels causing insulin resistance in skeletal muscle cells. Inhibition of GPx3 expression prevents the antioxidant effects of TZDs on insulin action in oxidative stress-induced insulin-resistant cells, suggesting that GPx3 is required for the regulation of PPARgamma-mediated antioxidant effects. Furthermore, reduced plasma GPx3 levels were found in patients with type 2 diabetes mellitus and in db/db/DIO mice. Collectively, these results suggest that the antioxidant effect of PPARgamma is exclusively mediated by GPx3 and further imply that GPx3 may be a therapeutic target for insulin resistance and diabetes mellitus. | en |
dc.description.sponsorship | This study was supported by 21C Frontier Functional Proteomics
Project from the Korean Ministry of Education, Science and Technology and MarineBio21, Ministry of Maritime Affairs and Fisheries, South Korea. | en |
dc.language.iso | en | en |
dc.publisher | American Society for Microbiology | en |
dc.subject | Animals | en |
dc.subject | Antioxidants/*metabolism | en |
dc.subject | Biological Transport/drug effects | en |
dc.subject | Diabetes Mellitus/enzymology | en |
dc.subject | Disease Models, Animal | en |
dc.subject | Extracellular Space/drug effects/metabolism | en |
dc.subject | Glucose/metabolism | en |
dc.subject | Glutathione Peroxidase/*metabolism | en |
dc.subject | Humans | en |
dc.subject | Hydrogen Peroxide/metabolism | en |
dc.subject | Insulin/metabolism | en |
dc.subject | Intracellular Space/drug effects/metabolism | en |
dc.subject | Mice | en |
dc.subject | Mice, Inbred C57BL | en |
dc.subject | Muscle Cells/drug effects/*enzymology | en |
dc.subject | Muscle, Skeletal/*cytology/*enzymology | en |
dc.subject | PPAR gamma/*metabolism | en |
dc.subject | Response Elements | en |
dc.subject | Signal Transduction/drug effects | en |
dc.subject | Thiazolidinediones/pharmacology | en |
dc.title | Glutathione peroxidase 3 mediates the antioxidant effect of peroxisome proliferator-activated receptor gamma in human skeletal muscle cells | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 정성수 | - |
dc.contributor.AlternativeAuthor | 김민 | - |
dc.contributor.AlternativeAuthor | 윤병수 | - |
dc.contributor.AlternativeAuthor | 이남석 | - |
dc.contributor.AlternativeAuthor | 박지우 | - |
dc.contributor.AlternativeAuthor | 이인규 | - |
dc.contributor.AlternativeAuthor | 김재범 | - |
dc.contributor.AlternativeAuthor | 조영민 | - |
dc.contributor.AlternativeAuthor | 이홍규 | - |
dc.contributor.AlternativeAuthor | 박경수 | - |
dc.contributor.AlternativeAuthor | 이윤석 | - |
dc.identifier.doi | 10.1128/MCB.00544-08 | - |
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