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Nutritional deficit as a negative prognostic factor in patients with miliary tuberculosis

Cited 41 time in Web of Science Cited 49 time in Scopus
Authors
Kim, D K; Kim, H J; Kwon, S-Y; Yoon, H-I; Lee, C-T; Kim, Y W; Chung, H S; Han, S K; Shim, Y-S; Lee, J-H
Issue Date
2008-05-30
Publisher
European Respiratory Society
Citation
Eur Respir J. 2008t; 32(4): 1031-1036
Keywords
AdultAgedFemaleHumansLung Diseases/diagnosisMaleMiddle AgedMultivariate AnalysisNutrition Disorders/complications/*diagnosisPrognosisRespiratory InsufficiencyRetrospective StudiesRisk FactorsTreatment OutcomeTuberculosis, Miliary/*diagnosis/epidemiology
Abstract
The effects of malnutrition on outcomes in miliary tuberculosis (MTB) are not well described. The aim of the present study was to find predictors for the development of acute respiratory failure (ARF) and survival in MTB patients, focusing on parameters reflecting nutritional condition. Out of the patients from three hospitals who had microbiologically or histopathologically confirmed tuberculosis, 56 patients presenting with typical disseminated pulmonary nodules on radiographs were retrospectively enrolled. A four-point nutritional risk score (NRS) was defined according to the presence of four nutritional factors: low body mass index (BMI; <18.5 kg x m(-2)), hypoalbuminaemia (<30.0 g x L(-1)), hypocholesterolaemia (<2.33 mmol x L(-1)) and severe lymphocytopenia (<7 x 10(5) cells x L(-1)). The male to female ratio was 1:3. ARF developed in 25% of patients (14 out of 56), with a 50% fatality rate. A high NRS (> or =3 points) was an independent risk factor for the development of ARF and fatality. In 90-day survival analysis, ARF, severe lymphocytopenia, hypocholesterolaemia, low BMI and higher NRS were risk factors for poor outcome. In multivariate analysis, only high NRS was an independent risk factor for 90-day survival rate in patients with MTB. A high nutritional risk score was a good predictor of poor outcome in miliary tuberculosis patients. Additional approaches to recover the nutritional deficits may become a focus in future management of miliary tuberculosis.
ISSN
1399-3003 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18508814

http://erj.ersjournals.com/cgi/reprint/32/4/1031.pdf

http://hdl.handle.net/10371/68202
DOI
https://doi.org/10.1183/09031936.00174907
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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