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N-myc amplification was rarely detected by fluorescence in situ hybridization in retinoblastoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jeong Hun | - |
dc.contributor.author | Choi, Jin Mi | - |
dc.contributor.author | Yu, Young Suk | - |
dc.contributor.author | Kim, Dong Hun | - |
dc.contributor.author | Kim, Jin Hyoung | - |
dc.contributor.author | Kim, Kyu-Won | - |
dc.date.accessioned | 2010-07-04T23:37:13Z | - |
dc.date.available | 2010-07-04T23:37:13Z | - |
dc.date.issued | 2008-06-10 | - |
dc.identifier.citation | Hum Pathol. 2008;39(8):1172-1175 | en |
dc.identifier.issn | 1532-8392 (Electronic) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18538370 | - |
dc.identifier.uri | http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WGD-4SNXT39-1-3&_cdi=6820&_user=168665&_orig=search&_coverDate=08%2F31%2F2008&_sk=999609991&view=c&wchp=dGLbVtz-zSkWA&md5=0a8a6132ca648aa53b24e17dfce7798b&ie=/sdarticle.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/68205 | - |
dc.description.abstract | In retinoblastoma, genetic alteration of N-myc amplification different from the alteration of the RB1 gene on chromosome 13q14 has been described. This study is to determine the frequency of N-myc amplification by fluorescence in situ hybridization method in retinoblastoma. This study was prospectively derived from 26 patients who were diagnosed as having unilateral retinoblastoma (highly progressive large retinoblastoma, group 5 in Reese-Ellsworth classification) and underwent enucleation. We performed locus-specific fluorescence in situ hybridization probes for N-myc gene. Our results demonstrated that in only one of 26 patients was N-myc amplification found in retinoblastoma tissue. N-myc amplification has been regarded as one characteristic of retinoblastoma cell line and an adverse prognostic factor. However, our study indicates that N-myc amplification is not frequently found in retinoblastoma. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Adolescent | en |
dc.subject | Adult | en |
dc.subject | Child | en |
dc.subject | Eye Neoplasms/*genetics | en |
dc.subject | Female | en |
dc.subject | Genes, myc/*genetics | en |
dc.subject | Genetic Markers | en |
dc.subject | Humans | en |
dc.subject | In Situ Hybridization, Fluorescence | en |
dc.subject | Male | en |
dc.subject | Retinoblastoma/*genetics | en |
dc.subject | Gene Amplification | - |
dc.title | N-myc amplification was rarely detected by fluorescence in situ hybridization in retinoblastoma | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김정훈 | - |
dc.contributor.AlternativeAuthor | 최진미 | - |
dc.contributor.AlternativeAuthor | 유영석 | - |
dc.contributor.AlternativeAuthor | 김동훈 | - |
dc.contributor.AlternativeAuthor | 김진형 | - |
dc.contributor.AlternativeAuthor | 김규원 | - |
dc.identifier.doi | 10.1016/j.humpath.2007.12.008 | - |
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