Publications
Detailed Information
Predictors of bronchial hyperresponsiveness in chronic rhinosinusitis with nasal polyp
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Han, D H | - |
dc.contributor.author | Kim, S W | - |
dc.contributor.author | Cho, S H | - |
dc.contributor.author | Kim, D Y | - |
dc.contributor.author | Lee, C H | - |
dc.contributor.author | Kim, S S | - |
dc.contributor.author | Rhee, C S | - |
dc.date.accessioned | 2010-07-04T23:53:16Z | - |
dc.date.available | 2010-07-04T23:53:16Z | - |
dc.date.issued | 2009-01-06 | - |
dc.identifier.citation | Allergy. 2009;64(1):118-122 | en |
dc.identifier.issn | 1398-9995 (Electronic) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19120071 | - |
dc.identifier.uri | https://hdl.handle.net/10371/68214 | - |
dc.description.abstract | BACKGROUND: Chronic rhinosinusitis with nasal polyposis (CRSNP) and asthma are inflammatory lesions of the respiratory epithelium. This study was conducted to evaluate predictive factors of bronchial hyperresponsiveness (BHR) in patients with CRSNP. METHODS: BHR was evaluated using a methacholine bronchoprovocation test (MBPT) in 122 consecutive patients newly diagnosed with CRSNP at Seoul National University Hospital from January 2004 to June 2006. The following parameters were analyzed and compared between the BHR and non-BHR groups: symptoms, atopic status, current smoking, disease severity of CRSNP based on the Lund-Mackay scoring system of sinus CT, and counts of eosinophils in the serum and nasal tissues. RESULTS: Thirty-five percent of the patients were found to have BHR, and BHR was found to occur more frequently in patients that were currently suffering from sneezing (P = 0.007). In addition, the mean eosinophil counts of the serum and nasal tissues were higher in the BHR group than in the non-BHR group (P = 0.001 for the serum, P = 0.045 for the nasal tissues), and the eosinophil counts of the serum correlated to those of the nasal tissues (r = 0.334, P = 0.013). The disease severity, as determined by the Lund-Mackay scoring system, was not different between the two groups (P > 0.05). The best cutoff serum eosinophil count for predicting BHR in CRSNP patients was determined to be 300 cells/microl (sensitivity 70%, specificity 70%). CONCLUSION: Taken together, these results indicate that moderate to severe sneezing and a serum eosinophil count > or = 300 cells/microl may be predictive factors for BHR in patients with CRSNP. | en |
dc.language.iso | en | en |
dc.publisher | Wiley-Blackwell | en |
dc.subject | Adolescent | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Aged, 80 and over | en |
dc.subject | Bronchial Hyperreactivity/*diagnosis | en |
dc.subject | Bronchial Provocation Tests | en |
dc.subject | Cell Count | en |
dc.subject | Chronic Disease | en |
dc.subject | Eosinophils/pathology | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Nasal Polyps/*complications | en |
dc.subject | Rhinitis/*complications | en |
dc.subject | Sensitivity and Specificity | en |
dc.subject | Severity of Illness Index | en |
dc.subject | Sinusitis/*complications | en |
dc.subject | Sneezing | en |
dc.subject | Young Adult | en |
dc.subject | Predictive Value of Tests | - |
dc.title | Predictors of bronchial hyperresponsiveness in chronic rhinosinusitis with nasal polyp | en |
dc.type | Article | en |
dc.identifier.doi | 10.1111/j.1398-9995.2008.01841.x | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.