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Associations between macular findings by optical coherence tomography and visual outcomes after epiretinal membrane removal

Cited 176 time in Web of Science Cited 204 time in Scopus
Authors
Suh, Min Hee; Seo, Jong Mo; Park, Kyu Hyung; Yu, Hyeong Gon
Issue Date
2008-12-05
Publisher
Elsevier
Citation
Am J Ophthalmol. 2009;147(3):473-480
Keywords
AgedCataract ExtractionEpiretinal Membrane/physiopathology/*surgeryFemaleFluorescein AngiographyHumansMacula Lutea/*pathologyMaleMiddle AgedProspective StudiesRetinal Photoreceptor Cell Inner Segment/*pathologyRetinal Photoreceptor Cell Outer Segment/*pathology*Tomography, Optical CoherenceTreatment OutcomeVisual Acuity/*physiology*Vitrectomy
Abstract
PURPOSE: To identify characteristics measured by optical coherence tomography (OCT) that are correlated with visual outcome after epiretinal membrane (ERM) removal by pars plana vitrectomy (PPV). DESIGN: Interventional, prospective, randomized case series. METHODS: One hundred and one eyes of 101 patients with idiopathic ERM underwent PPV for ERM removal. Ophthalmic evaluations included best-corrected visual acuity (BCVA) and Stratus OCT preoperatively at 3 and 6 months postoperatively. Relations between three OCT features including integrity of junction between inner and outer segments of photoreceptors (IS/OS junction), macular thickness, foveal contour and the three visual acuity parameters such as preoperative BCVAs, postoperative BCVAs, and the differences between preoperative and postoperative BCVAs (BCVA differences) were evaluated with respect to time. RESULTS: Eyes with disruption of IS/OS junction had significantly lower postoperative BCVA and BCVA differences than those without disruption (P < .0001, respectively). "Same" (increment or decrement of BCVA up to 1 Snellen line) and "Better" (visual increment of at least 2 Snellen lines) BCVA outcome groups were significantly different with respect to the status of IS/OS junction (P < .005). An increase in the proportion of eyes with photoreceptor disruption was observed at 3 months postoperatively, and this proportion was maintained afterward. Preoperative macular thicknesses showed a positive correlation with BCVA differences, and postoperative macular thicknesses negatively correlated with postoperative BCVA (r > 0.25; P < .05, respectively). Thickness difference and foveal contour were not correlated with the three parameters of visual outcome (P > .05, respectively). CONCLUSION: Photoreceptor disruption detected by OCT was found to be a predictor of poor visual outcome in eyes with idiopathic ERM, and it was found that this disruption may be irreversible. Thus, early membrane removals may beneficially prevent further progression of photoreceptor damage in ERM patients with photoreceptor disruption.
ISSN
1879-1891 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19054492

http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6VK5-4V2G7K3-5-K&_cdi=6113&_user=168665&_orig=search&_coverDate=03%2F31%2F2009&_sk=998529996&view=c&wchp=dGLbVzz-zSkzV&md5=1b067817e9ec74bc5f3379cbd267aae8&ie=/sdarticle.pdf

https://hdl.handle.net/10371/68226
DOI
https://doi.org/10.1016/j.ajo.2008.09.020
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College of Medicine/School of Medicine (의과대학/대학원)Ophthalmology (안과학전공)Journal Papers (저널논문_안과학전공)
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