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Effect of travoprost on intraocular pressure during 12 months of treatment for normal-tension glaucoma

Cited 19 time in Web of Science Cited 23 time in Scopus
Authors
Suh, Min Hee; Park, Ki Ho; Kim, Dong Myung
Issue Date
2009-02-03
Publisher
Elsevier
Citation
Jpn J Ophthalmol. 2009;53(1):18-23
Keywords
Antihypertensive Agents/adverse effects/*therapeutic useCloprostenol/adverse effects/*analogs & derivatives/therapeutic useFemaleFollow-Up StudiesGlaucoma, Open-Angle/*drug therapyHumansIntraocular Pressure/*drug effectsMaleMiddle AgedTonometry, Ocular
Abstract
PURPOSE: To evaluate the intraocular pressure (IOP)-lowering effect of travoprost in normal-tension glaucoma (NTG) over a 12-month follow-up. METHODS: Forty-five eyes of 45 patients with unilateral NTG were treated with travoprost (0.004%) once a day for 12 months. Mean IOP and the IOP reduction from baseline were assessed at 0.5, 1, 3, 6, 9, and 12 months after the initiation of the treatment. Adverse ocular event frequency and the frequency of discontinuation of treatment due to adverse events were evaluated. RESULTS: Mean IOP during 12 months of travoprost treatment ranged from 11.17 to 11.82 mmHg, and the mean IOP reduction in relation to baseline IOP from -2.71 to -3.71 mmHg (-18.3% to -25.1%). Mean IOP and IOP changes in the travoprost-treated and control groups were significantly different at every follow-up (P < 0.05 in each case). Both the magnitude (r = 0.6992) and percentage (r = 0.5464) of IOP reductions correlated positively with baseline IOP values. Ocular adverse events were usually mild to moderate and resolved without treatment. CONCLUSIONS: Travoprost was well tolerated and significantly reduced IOP in NTG patients. In addition, initial IOP reductions were maintained throughout follow-up. Travoprost was found to be more effective in patients with greater baseline IOP.
ISSN
1613-2246 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19184304

http://www.springerlink.com/content/b5704u87g8458884/fulltext.pdf

http://hdl.handle.net/10371/68229
DOI
https://doi.org/10.1007/s10384-008-0617-8
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College of Medicine/School of Medicine (의과대학/대학원)Ophthalmology (안과학전공)Journal Papers (저널논문_안과학전공)
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