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Comparison of retinal nerve fibre layers between 11778 and 14484 mutations in Leber's hereditary optic neuropathy

Cited 13 time in Web of Science Cited 15 time in Scopus
Authors
Seo, J. H.; Hwang, J. M.; Park, S. S.
Issue Date
2010
Publisher
Nature Publishing Group
Citation
Eye 2010; 24: 107-111
Abstract
PurposeTo compare retinal nerve fibre layer (RNFL) thickness changes between mitochondrial DNA (mtDNA) mutations at nucleotides 11778 and 14484 in Leber's hereditary optic neuropathy (LHON) using optical coherence tomography (OCT).MethodsThirty LHON patients with mtDNA mutations at nucleotides 11778 or 14484 underwent full ophthalmologic examinations including Stratus OCT. Patients were divided into four groups according to disease duration (early6 months) and mtDNA mutation type (11778 and 14484), and their RNFL thicknesses were compared.ResultsAverage RNFL thickness in the early 11778 group was significantly greater than that in the early 14484 group (P=0.04). Average RNFL thickness in the late 11778 group was significantly less than that in the late 14484 group (P=0.02). Quadrant analysis of the superior, nasal, and inferior quadrant RNFL thickness in the late 11778 group showed more severe RNFL atrophy than in the late 14484 group (P=0.023, 0.015, 0.003, respectively).ConclusionsRNFL thickness was significantly increased in the early stage and decreased in the late stage in the 11778 group than in the 14484 group.Eye advance online publication, 27 February 2009; doi:10.1038/eye.2009.36.
ISSN
1476-5454 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19247386

http://www.nature.com/eye/journal/vaop/ncurrent/pdf/eye200936a.pdf

https://hdl.handle.net/10371/68241
DOI
https://doi.org/10.1038/eye.2009.36
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College of Medicine/School of Medicine (의과대학/대학원)Ophthalmology (안과학전공)Journal Papers (저널논문_안과학전공)
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