Publications
Detailed Information
Flow cytometric assessment of anti-neuronal antibodies in central nervous system involvement of systemic lupus erythematosus and other autoimmune diseases
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, E H | - |
dc.contributor.author | Shen, G Q | - |
dc.contributor.author | Morris, R | - |
dc.contributor.author | Metzger, A | - |
dc.contributor.author | Lee, E Y | - |
dc.contributor.author | Lee, Y J | - |
dc.contributor.author | Lee, E B | - |
dc.contributor.author | Song, Y W | - |
dc.date.accessioned | 2010-07-05T01:39:37Z | - |
dc.date.available | 2010-07-05T01:39:37Z | - |
dc.date.issued | 2007-12-20 | - |
dc.identifier.citation | Lupus. 2008; 17(1): 21-25 | en |
dc.identifier.issn | 0961-2033 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18089679 | - |
dc.identifier.uri | http://lup.sagepub.com/cgi/reprint/17/1/21.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/68242 | - |
dc.description.abstract | The objective of this study is to evaluate the association between anti-neuronal antibody (anti-NA) and central nervous system (CNS) manifestations of systemic lupus erythematosus (SLE) and other rheumatic diseases using a flow cytometric method. Anti-NA was measured by flow cytometry in serum and cerebrospinal fluid (CSF) samples from patients with SLE (n=44 for serum, n=17 for CSF), other rheumatic diseases (n=64 for serum, n=21 for CSF) and from healthy controls (n=65 for serum, n=18 for CSF). Serum anti-NA was more frequently observed in SLE (31.8%, 14/44) than in other rheumatic diseases (4.7%, 3/64, P<0.001) or in healthy controls (0%, 0/65, P<0.00001). In SLE patients, the frequency of serum anti-NA was significantly higher in CNS-SLE (76.5%, 13/17) than in non CNS-SLE (3.7%, 1/27, P<0.000001). CSF anti-NA was detected in 88.2% (15/17) of CNS-SLE and was more frequently detected in CNS-SLE (15/17, 88.2%) than in other rheumatic diseases with CNS involvement (1/21, 4.8%, P<0.000001) or in healthy controls (0/18, P<0.000001). In conclusion, serum anti-NA was more frequently found in CNS-SLE than in non CNS-SLE, other rheumatic diseases or in healthy controls. The frequency of CSF anti-NA in CNS-SLE was significantly higher than in other rheumatic diseases with CNS involvement or in healthy controls. | en |
dc.description.sponsorship | This work was supported by the Korea Science and
Engineering Foundation (KOSEF) through the National Research Lab. Program funded by the Ministry of Science and Technology. | en |
dc.language.iso | en | en |
dc.publisher | SAGE Publications | en |
dc.subject | Adult | en |
dc.subject | Cell Line, Tumor | en |
dc.subject | Cerebrovascular Disorders/immunology | en |
dc.subject | Confusion/immunology | en |
dc.subject | Epilepsy/immunology | en |
dc.subject | Female | en |
dc.subject | Headache Disorders/immunology | en |
dc.subject | Humans | en |
dc.subject | Lupus Erythematosus, Systemic/complications/*immunology | en |
dc.subject | Lupus Vasculitis, Central Nervous System/complications/*immunology | en |
dc.subject | Male | en |
dc.subject | Meningitis, Aseptic/immunology | en |
dc.subject | Middle Aged | en |
dc.subject | Neurons/*immunology | en |
dc.subject | Psychotic Disorders/immunology | en |
dc.subject | Rheumatic Diseases/complications/*immunology | en |
dc.subject | Up-Regulation | en |
dc.subject | Autoantibodies/blood/cerebrospinal fluid | - |
dc.subject | Flow Cytometry | - |
dc.title | Flow cytometric assessment of anti-neuronal antibodies in central nervous system involvement of systemic lupus erythematosus and other autoimmune diseases | en |
dc.type | Article | en |
dc.identifier.doi | 10.1177/0961203307085256 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.