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Circulating endothelial progenitor cells as a pathogenetic marker of moyamoya disease

Cited 42 time in Web of Science Cited 46 time in Scopus
Authors
Jung, Keun-Hwa; Chu, Kon; Lee, Soon-Tae; Park, Hee-Kwon; Kim, Dong-Hyun; Kim, Jin-Hee; Bahn, Jae-Jun; Song, Eun-Cheol; Kim, Manho; Lee, Sang Kun; Roh, Jae-Kyu
Issue Date
2008-07-10
Publisher
Nature Publishing Group
Citation
J Cereb Blood Flow Metab. 28(11):1795-1803
Keywords
AdultAnastomosis, SurgicalBiological Markers/*bloodCerebral AngiographyCerebral Arteries/surgeryCerebral Hemorrhage/epidemiologyCollagen*Colony-Forming Units AssayDrug CombinationsFemaleHumansIschemic Attack, Transient/epidemiologyLamininLeukocytes, Mononuclear/*pathologyMaleMiddle AgedMoyamoya Disease/*blood/classification/pathology/radiographyProteoglycansReference ValuesRisk FactorsStroke/classification/epidemiologyTemporal Arteries/surgery
Abstract
Moyamoya disease (MMD) is an unusual form of chronic cerebrovascular occlusive disease that involves the formation of characteristically abnormal vessels. Recent studies have reported that colony-forming unit (CFU) and outgrowth cells represent a subpopulation of endothelial progenitor cells (EPCs). Here, we attempted to determine the significance of CFU number and outgrowth cell yield in MMD. Endothelial progenitor cells were isolated from the blood of 24 adult MMD patients and from 48 age- and risk factor-matched control subjects. After 7 days of culture, CFUs were determined, and yields of outgrowth cells were measured during 2 months of culture. The EPC function was also evaluated using matrigel plate assays. It was found that CFU numbers were significantly lower in MMD patients than in controls. Moreover, during long-term culture, outgrowth cells were isolated from only 10% of control subjects but from 33% of MMD patients, and CFU numbers and tube formation were found to be lower in advanced MMD cases than in those with early stage disease, whereas outgrowth cells were more frequently detected in those with early MMD and moyamoya vessels than in those with advanced disease. These characteristics of circulating EPCs reflect mixed conditions of vascular occlusion and abnormal vasculogenesis during the pathogenesis of MMD.
ISSN
1559-7016 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18612318

http://www.nature.com/jcbfm/journal/v28/n11/pdf/jcbfm200867a.pdf

http://hdl.handle.net/10371/68376
DOI
https://doi.org/10.1038/jcbfm.2008.67
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Neurology (신경과학교실)Journal Papers (저널논문_신경과학교실)
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