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Augmentation of nitrite therapy in cerebral ischemia by NMDA receptor inhibition

Cited 31 time in Web of Science Cited 29 time in Scopus
Authors
Jung, Keun-Hwa; Chu, Kon; Lee, Soon-Tae; Park, Hee-Kwon; Kim, Jin-Hee; Kang, Kyung-Muk; Kim, Manho; Lee, Sang Kun; Roh, Jae-Kyu
Issue Date
2009
Publisher
Elsevier
Citation
Biochem Biophys Res Commun. 378 (2009) 507-512
Keywords
AnimalsBrain Ischemia/*drug therapyDisease Models, AnimalDrug Therapy, CombinationExcitatory Amino Acid Antagonists/*therapeutic useMaleMemantine/*therapeutic useNeuroprotective Agents/*therapeutic useOxidative Stress/drug effectsRatsRats, Sprague-DawleyReceptors, N-Methyl-D-Aspartate/*antagonists & inhibitorsSodium Nitrite/*therapeutic useStroke/*drug therapy
Abstract
Our recent work suggested that early infusion of nitrite might represent a novel therapeutic approach for acute ischemic stroke. In this study, we sought to examine the therapeutic time window of nitrite in an experimental stroke model, and to develop combined strategies for augmenting its protective effects. Nitrite was infused at various times after ischemia to rats subjected to transient or permanent focal ischemia. Nitrite was infused with memantine to prevent the potential toxicity. Infarct volumes, functional outcomes, microhypoxic areas, and oxidative stress were measured. Nitrite reduced the infarction volume and enhanced functional recovery when administered within 3 and 1.5h in the transient and permanent model, respectively. Combined therapy with nitrite and memantine prolonged the time window up to 4.5h. The potential oxidative toxicities of nitrite were significantly inhibited by memantine. The combination therapy of nitrite and memantine may be a feasible therapeutic approach for acute ischemic stroke.
ISSN
1090-2104 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19056343

http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WBK-4V2NSG0-9-G&_cdi=6713&_user=168665&_orig=search&_coverDate=01%2F16%2F2009&_sk=996219996&view=c&wchp=dGLbVlz-zSkWA&md5=7e4e16d96df6d9c14df7fb79d261c431&ie=/sdarticle.pdf

http://hdl.handle.net/10371/68378
DOI
https://doi.org/10.1016/j.bbrc.2008.11.081
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Neurology (신경과학교실)Journal Papers (저널논문_신경과학교실)
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