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Novel pattern of levodopa-related motor fluctuations: 'paradoxical'on

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Issue Date
2007-11-06
Publisher
Elsevier
Citation
Parkinsonism Relat Disord. 2008;14(4):281-285
Keywords
AgedAntiparkinson Agents/*adverse effectsFemaleHumansLevodopa/*adverse effectsMaleMiddle AgedMovement Disorders/*etiologyParkinsonian Disorders/drug therapy
Abstract
Generally, motor functions of Parkinson disease (PD) patients become worse as levodopa wears off. Recently, we encountered four PD patients who reported that their motor functions get better after levodopa wears off. These patients were admitted and the pattern of motor fluctuations was monitored. All showed a novel pattern where motor function spontaneously got better near to on level without medication after the effect of levodopa wore off. We call this 'paradoxical'on because motor functions get paradoxically better when levodopa is most likely washed out from the body. Pathomechanism of 'paradoxical'on is uncertain and needs further investigation.
ISSN
1353-8020 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17980642

http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6TB9-4R2HKWM-1-5&_cdi=5137&_user=168665&_orig=search&_coverDate=05%2F31%2F2008&_sk=999859995&view=c&wchp=dGLzVtb-zSkzV&md5=7b1bee2df8f22a4f72c2a9f72c61add1&ie=/sdarticle.pdf

https://hdl.handle.net/10371/68399
DOI
https://doi.org/10.1016/j.parkreldis.2007.09.001
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Neurology (신경과학교실)Journal Papers (저널논문_신경과학교실)
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