S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Neurology (신경과학교실) Journal Papers (저널논문_신경과학교실)
Novel pattern of levodopa-related motor fluctuations: 'paradoxical'on
- Issue Date
- Parkinsonism Relat Disord. 2008;14(4):281-285
- Aged ; Antiparkinson Agents/*adverse effects ; Female ; Humans ; Levodopa/*adverse effects ; Male ; Middle Aged ; Movement Disorders/*etiology ; Parkinsonian Disorders/drug therapy
- Generally, motor functions of Parkinson disease (PD) patients become worse as levodopa wears off. Recently, we encountered four PD patients who reported that their motor functions get better after levodopa wears off. These patients were admitted and the pattern of motor fluctuations was monitored. All showed a novel pattern where motor function spontaneously got better near to on level without medication after the effect of levodopa wore off. We call this 'paradoxical'on because motor functions get paradoxically better when levodopa is most likely washed out from the body. Pathomechanism of 'paradoxical'on is uncertain and needs further investigation.
- 1353-8020 (Print)
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