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Glial expression of interleukin-18 and its receptor after excitotoxic damage in the mouse hippocampus
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeon, Gye Sun | - |
dc.contributor.author | Park, Sung Kyung | - |
dc.contributor.author | Park, Sang Wook | - |
dc.contributor.author | Kim, Dong Woon | - |
dc.contributor.author | Chung, Chun Kee | - |
dc.contributor.author | Cho, Sa Sun | - |
dc.date.accessioned | 2010-07-07T03:12:12Z | - |
dc.date.available | 2010-07-07T03:12:12Z | - |
dc.date.issued | 2007-08-22 | - |
dc.identifier.citation | Neurochem Res. 33(1):179-184 | en |
dc.identifier.issn | 0364-3190 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17710540 | - |
dc.identifier.uri | http://www.springerlink.com/content/l440771644462741/fulltext.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/68408 | - |
dc.description.abstract | Interleukin (IL)-18, a member of the IL-1 cytokine family, is an important mediator of peripheral inflammation and host defence responses. However, although IL-1 is a key proinflammatory cytokine in the brain, little is known about IL-18 changes in glial cells under excitotoxic neurodegeneration. In this study, we characterized the expressions of IL-18 and IL-18 receptor (IL-18R) in kainic acid (KA)-induced excitotoxicity in mouse hippocampus by immunohistochemistry and Western blotting. IL-18 immunoreactivity was found in microglia whereas IL-18R immunoreactivity was observed in astrocytes. Levels of IL-18 and IL-18R in hippocampus homogenates increased progressively from day 1 post-KA and peaked at 3 days. This study demonstrates the cellular sources of IL-18 and IL-18R, and their temporal correlations after KA-insult, and suggests roles for IL-18 and IL-18R in glial cells in response to excitotoxic damage in the hippocampus. | en |
dc.description.sponsorship | This study was supported by the second stage
Brain Korea 21 Project in 2007 and a grant (M103KV010018 04K2201 01850) from Brain Research Center of the 21st Century Frontier Research Program funded by the Ministry of Science and Technology, the Republic of Korea. | en |
dc.language.iso | en | en |
dc.publisher | Springer Verlag | en |
dc.subject | Animals | en |
dc.subject | Blotting, Western | en |
dc.subject | Hippocampus/*drug effects/metabolism | en |
dc.subject | Immunohistochemistry | en |
dc.subject | Interleukin-18/*metabolism | en |
dc.subject | Kainic Acid/*toxicity | en |
dc.subject | Male | en |
dc.subject | Mice | en |
dc.subject | Mice, Inbred ICR | en |
dc.subject | Neuroglia/*metabolism | en |
dc.subject | Receptors, Interleukin-18/*metabolism | en |
dc.title | Glial expression of interleukin-18 and its receptor after excitotoxic damage in the mouse hippocampus | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 전계선 | - |
dc.contributor.AlternativeAuthor | 박성경 | - |
dc.contributor.AlternativeAuthor | 박상욱 | - |
dc.contributor.AlternativeAuthor | 김동운 | - |
dc.contributor.AlternativeAuthor | 정천기 | - |
dc.contributor.AlternativeAuthor | 조사선 | - |
dc.identifier.doi | 10.1007/s11064-007-9434-6 | - |
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