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Diffusion tensor imaging in idiopathic acute transverse myelitis

Cited 20 time in Web of Science Cited 26 time in Scopus
Authors
Lee, Joon Woo; Park, Kyung Seok; Kim, Jae Hyoung; Choi, Ja-Young; Hong, Sung Hwan; Park, Seong-Ho; Kang, Heung Sik
Issue Date
2008-07-24
Publisher
American Roentgen Ray Society
Citation
AJR Am J Roentgenol. 2008; 191(2):W52-W57
Keywords
AdultAgedAnisotropyCase-Control StudiesCervical Vertebrae*Diffusion Magnetic Resonance ImagingFemaleHumansMaleMiddle AgedMyelitis, Transverse/*pathologyStatistics, Nonparametric
Abstract
OBJECTIVE: Our study was based on our hypotheses that in idiopathic acute transverse myelitis (ATM), fractional anisotropy (FA) values would be abnormal not only in the T2-hyperintense lesion but also in the surrounding normal-appearing spinal cord and that the abnormal FA values in the spinal cord could be related to clinical outcome. SUBJECTS AND METHODS: Sagittal diffusion tensor imaging (DTI) was performed in 10 patients with idiopathic ATM (four men, six women; mean age, 45 years; age range, 20-66 years) and 10 sex- and age-matched normal volunteers. FA measurements were made in the spinal cord at three levels: lesion, proximal normal-appearing spinal cord, and distal normal-appearing spinal cord. The grade of FA decrease (mild, less than 10% decrease [(FA normal - FA pt) x 100 / FA normal]; moderate, 10-20%; severe, more than 20%) was related to the clinical outcome, which was determined by a neurologist using Paine's scale of normal, good, fair, or poor. RESULTS: Mean FA values in patients were significantly lower than those in normal volunteers in lesions (0.5328 vs 0.7125, p = 0.002) and distal normal-appearing spinal cord (0.6676 vs 0.7720, p = 0.0137). All three patients with a mild FA decrease or increase in distal normal-appearing spinal cord showed a normal or good outcome, but all three patients with a severe FA decrease in distal normal-appearing spinal cord showed a fair outcome, among the eight patients to whom steroid treatment was given. CONCLUSION: FA values in lesions and in distal normal-appearing spinal cord significantly decreased in patients with idiopathic ATM, and FA decrease in distal normal-appearing spinal cord might be related to clinical outcome.
ISSN
1546-3141 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18647886

http://www.ajronline.org/cgi/reprint/191/2/W52.pdf

https://hdl.handle.net/10371/68435
DOI
https://doi.org/10.2214/AJR.07.2800
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Neurology (신경과학교실)Journal Papers (저널논문_신경과학교실)
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