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Granulocyte-colony stimulating factor attenuates striatal degeneration with activating survival pathways in 3-nitropropionic acid model of Huntington's disease
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Soon-Tae | - |
dc.contributor.author | Park, Jung-Eun | - |
dc.contributor.author | Kim, Dong-Hyun | - |
dc.contributor.author | Kim, Seungchan | - |
dc.contributor.author | Im, Woo-Seok | - |
dc.contributor.author | Kang, Lami | - |
dc.contributor.author | Jung, Se Hee | - |
dc.contributor.author | Kim, Min-Wook | - |
dc.contributor.author | Chu, Kon | - |
dc.contributor.author | Kim, Manho | - |
dc.date.accessioned | 2010-07-07T04:10:15Z | - |
dc.date.available | 2010-07-07T04:10:15Z | - |
dc.date.issued | 2008-01-02 | - |
dc.identifier.citation | Brain Res. 1194, 130-137 | en |
dc.identifier.issn | 0006-8993 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18166168 | - |
dc.identifier.uri | http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6SYR-4R98K8V-1-F&_cdi=4841&_user=168665&_orig=search&_coverDate=02%2F15%2F2008&_sk=988059999&view=c&wchp=dGLbVzW-zSkzk&md5=929f5c8f417e6b2956f7027b3f138b51&ie=/sdarticle.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/68449 | - |
dc.description.abstract | Huntington's disease (HD) has a mitochondrial dysfunction causing the vulnerability to the excitotoxicity and activations of multiple cell death pathways. Recent evidences suggest that the hematopoietic cytokine, granulocyte-colony stimulating factor (G-CSF), exerts pleiotropic neuroprotection in acute neural injury with activating various survival pathways. Thus, we investigated whether G-CSF can modulate neurodegeneration in an HD animal model induced by 3-nitropropionic acid (3NP), which inhibits mitochondrial succinate dehydrogenase complex II. Either G-CSF (50 microg/kg/day) or saline (as vehicle) was administered intraperitoneally for 5 days with 3NP (63 mg/kg/day) continuous osmotic pump infusion into male Lewis rats. We measured motor scales (0-8) daily and sacrificed rats at 5 days. We observed that G-CSF receptors were expressed in 3NP-induced degenerating striatum. Rats treated with G-CSF showed less degree of neurologic deficits. In the G-CSF-treated rats, the striatal lesion volume measured by Nissl staining, TUNEL+ apoptotic cells, Fluorojade C+ degenerating neurons, and c-Jun+ cells were all decreased. In western blotting, G-CSF activated survival pathways including p-ERK, p-eNOS, p-STAT3, and p-Akt. In summary, G-CSF was found to have neuroprotective effects and save striatal cells through activations of survival pathways in the 3NP-induced striatal degeneration model for HD. | en |
dc.description.sponsorship | This work was supported by the research grant from the
Catholic Medical Center Research Foundation made in the program year of 2006. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Animals | en |
dc.subject | Corpus Striatum/drug effects/*pathology | en |
dc.subject | Disease Models, Animal | en |
dc.subject | Drug Interactions | en |
dc.subject | Gene Expression Regulation/drug effects/physiology | en |
dc.subject | Granulocyte Colony-Stimulating Factor/*therapeutic use | en |
dc.subject | Huntington Disease/*chemically induced/*complications | en |
dc.subject | In Situ Nick-End Labeling | en |
dc.subject | Male | en |
dc.subject | Organic Chemicals/diagnostic use | en |
dc.subject | Rats | en |
dc.subject | Rats, Inbred Lew | en |
dc.subject | Signal Transduction/*drug effects/physiology | en |
dc.subject | Statistics, Nonparametric | en |
dc.subject | Neurodegenerative Diseases/drug therapy/etiology/pathology | - |
dc.subject | Nitro Compounds | - |
dc.subject | Propionic Acids | - |
dc.title | Granulocyte-colony stimulating factor attenuates striatal degeneration with activating survival pathways in 3-nitropropionic acid model of Huntington's disease | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이순태 | - |
dc.contributor.AlternativeAuthor | 박정은 | - |
dc.contributor.AlternativeAuthor | 김동현 | - |
dc.contributor.AlternativeAuthor | 김승찬 | - |
dc.contributor.AlternativeAuthor | 임우석 | - |
dc.contributor.AlternativeAuthor | 강라미 | - |
dc.contributor.AlternativeAuthor | 정세희 | - |
dc.contributor.AlternativeAuthor | 김민욱 | - |
dc.contributor.AlternativeAuthor | 주건 | - |
dc.contributor.AlternativeAuthor | 김만호 | - |
dc.identifier.doi | 10.1016/j.brainres.2007.11.058 | - |
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