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The efficacy of combined estrogen and buspirone treatment in olivopontocerebellar atrophy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Heo, Jae-Hyeok | - |
dc.contributor.author | Lee, Soon-Tae | - |
dc.contributor.author | Chu, Kon | - |
dc.contributor.author | Kim, Manho | - |
dc.date.accessioned | 2010-07-07T23:09:38Z | - |
dc.date.available | 2010-07-07T23:09:38Z | - |
dc.date.issued | 2008-05-10 | - |
dc.identifier.citation | J Neurol Sci. 2008;271(1-2):87-90 | en |
dc.identifier.issn | 0022-510X (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18466925 | - |
dc.identifier.uri | http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T06-4SFR7XW-2-1&_cdi=4854&_user=168665&_orig=search&_coverDate=08%2F15%2F2008&_sk=997289998&view=c&wchp=dGLzVtb-zSkzk&md5=99f86ffeae71150d9b720e8ba706da0c&ie=/sdarticle.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/68465 | - |
dc.description.abstract | BACKGROUND: Olivopontocerebellar atrophy (OPCA) is a chronic neurodegenerative disease with symptoms of cerebellar ataxia, parkinsonism, autonomic disturbances and ophthalmoplegia. Buspirone, a 5-HT1(A) agonist could constitute a symptomatic improvement in cerebellar dysfunction whereas estrogen has been investigated for neuroprotection. We conducted an open-labeled pilot trial to assess the efficacy of estrogen with buspirone treatment. PATIENTS AND METHODS: Eighteen patients (7 male and 11 female) with OPCA were randomized into the buspirone (15 mg/day, n=9), or the combined treatment group (estrogen, 0.625 mg/d plus buspirone, n=9). For the clinical rating, International Cooperative Ataxia Rating Scale (ICARS) was used and dysarthria, gaze evoked nystagmus, finger to nose, pronation-supination alternating movement, knee-tibia test, and gait speed were evaluated for 12 months. RESULTS: Buspirone-treated group showed improvements in finger to nose and pronation-supination alternating movement test (p=0.046 and p=0.025, respectively). The combination group (Estrogen+buspirone), however, showed no improvement in cerebellar sub-scales compared to the baseline. CONCLUSIONS: Buspirone treatment showed feasible efficacies for OPCA, while the combined treatment of estrogen and buspirone failed to improve, suggesting estrogen may not have further benefit in cerebellar dysfunction. | en |
dc.description.sponsorship | This work was supported by grant (No.04-2007-067) from the
Seoul National University Hospital Research Fund. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Adult | en |
dc.subject | Buspirone/*therapeutic use | en |
dc.subject | Drug Therapy, Combination | en |
dc.subject | Estrogens/*therapeutic use | en |
dc.subject | Evaluation Studies as Topic | en |
dc.subject | Female | en |
dc.subject | Follow-Up Studies | en |
dc.subject | Humans | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Olivopontocerebellar Atrophies/*drug therapy | en |
dc.subject | Serotonin Agonists/*therapeutic use | en |
dc.subject | Severity of Illness Index | en |
dc.title | The efficacy of combined estrogen and buspirone treatment in olivopontocerebellar atrophy | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 허재혁 | - |
dc.contributor.AlternativeAuthor | 이순태 | - |
dc.contributor.AlternativeAuthor | 주건 | - |
dc.contributor.AlternativeAuthor | 김만호 | - |
dc.identifier.doi | 10.1016/j.jns.2008.03.016 | - |
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