Browse

Prevalence of narcolepsy-cataplexy in Korean adolescents

Cited 27 time in Web of Science Cited 34 time in Scopus
Authors
Shin, Y K; Yoon, I Y; Han, E K; No, Y M; Hong, M C; Yun, Y D; Jung, B K; Chung, S H; Choi, J B; Cyn, J G; Lee, Y J; Hong, S C
Issue Date
2007-10-10
Publisher
Wiley-Blackwell
Citation
Acta Neurol Scand. 2008;117(4):273-278
Keywords
AdolescentAdultAge of OnsetAsian Continental Ancestry GroupDiagnosis, DifferentialFemaleGenotypeHLA Antigens/geneticsHumansInterviews as TopicKorea/epidemiologyMaleNarcolepsy/*diagnosis/*epidemiology/physiopathologyPolysomnographyPredictive Value of TestsPrevalenceQuestionnaires
Abstract
BACKGROUND: Narcolepsy typically begins between adolescence and early adulthood causing severe neuropsychiatric impairments, but few prevalence studies are available on adolescent narcoleptics. In the present study, we investigated the prevalence of narcolepsy-cataplexy in adolescents. METHODS: In total 20,407 students, aged 14-19 years, participated in this study. Ullanlinna Narcolepsy Scale (UNS) was applied to all subjects and those with a UNS score of > or =14 were contacted by phone for semi-structured interview. Subjects then suspected of having narcolepsy participated in a laboratory investigation, which included polysomnography and HLA typing, or were interviewed in detail by telephone. RESULTS: Three subjects were finally diagnosed as narcolepsy with cataplexy and seven subjects might be diagnosed as narcolepsy without cataplexy. Among three narcoleptics with cataplexy, two subjects were HLA-DQB1*0602 and DRB1*1501 positive, but one subject had no test of HLA typing. The prevalence of narcolepsy with cataplexy in Korean adolescence was thus determined to be 0.015% (95% confidence interval = 0.0-0.0313%). CONCLUSION: This epidemiologic study is the first of its type on adolescent narcolepsy to use the International Classification of Sleep Disorders, 2nd edition (ICSD-2) diagnostic criteria. Considering those cases with an onset after adolescence were not included, the prevalence of narcolepsy with cataplexy determined in the present study is comparable with that of other studies in adults.
ISSN
1600-0404 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17922892

https://hdl.handle.net/10371/68469
DOI
https://doi.org/10.1111/j.1600-0404.2007.00930.x
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse