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Intracoronary continuous adenosine infusion
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Koo, Bon-Kwon | - |
dc.contributor.author | Kim, Cheol-Ho | - |
dc.contributor.author | Na, Sang-Hun | - |
dc.contributor.author | Youn, Tae-Jin | - |
dc.contributor.author | Chae, In-Ho | - |
dc.contributor.author | Choi, Dong-Ju | - |
dc.contributor.author | Kim, Hyo-Soo | - |
dc.contributor.author | Lee, Myoung-Mook | - |
dc.contributor.author | Oh, Byung-Hee | - |
dc.contributor.author | Park, Young-Bae | - |
dc.contributor.author | Choi, Yun-Shik | - |
dc.contributor.author | Tahk, Seung-Jae | - |
dc.date.accessioned | 2010-07-07T23:40:22Z | - |
dc.date.available | 2010-07-07T23:40:22Z | - |
dc.date.issued | 2005-07-26 | - |
dc.identifier.citation | Circ J. 2005;69(8): 908-912 | en |
dc.identifier.issn | 1346-9843 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16041158 | - |
dc.identifier.uri | https://hdl.handle.net/10371/68475 | - |
dc.description.abstract | BACKGROUND: Various methods are used to induce maximal hyperemia for physiologic studies, but the feasibility and efficacy of continuous intracoronary (IC) infusion of adenosine for measurement of fractional flow reserve (FFR) has not been well-defined. METHODS AND RESULTS: Patients with intermediate coronary artery stenosis were consecutively enrolled. In the phase I study, FFR was measured after 3 dosages of IC adenosine infusion (180, 240 and 300 microg/min) in 30 patients. The phase II study was performed to compare the hyperemic efficacy of IC infusion (240 microg/min) with IC bolus injection (40, 80 microg) and intravenous (IV) infusion (140 microg x kg (-1) x min(-1)) of adenosine in 20 patients. In the phase I study, no significant differences in FFR were observed with the 3 different doses of IC infusion (p = 0.06). In the phase II study, FFR after an IC bolus injection (0.83+/-0.06) was significantly higher than with IV (0.79+/-0.07) or IC (0.78+/-0.09) infusion (p < 0.01). However, no difference in FFR was observed for IC and IV infusions. CONCLUSION: IC infusion of adenosine seems to be a safe and effective method of inducing maximal hyperemia for FFR measurement. | en |
dc.language.iso | en | en |
dc.publisher | The Japanese Circulation Society | en |
dc.subject | Adenosine/*administration & dosage | en |
dc.subject | Aged | en |
dc.subject | Blood Flow Velocity/drug effects | en |
dc.subject | Coronary Circulation/*drug effects | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Hyperemia/*chemically induced | en |
dc.subject | Infusions, Intra-Arterial | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Coronary Stenosis/drug therapy | - |
dc.title | Intracoronary continuous adenosine infusion | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 구본권 | - |
dc.contributor.AlternativeAuthor | 김철호 | - |
dc.contributor.AlternativeAuthor | 나상훈 | - |
dc.contributor.AlternativeAuthor | 윤태진 | - |
dc.contributor.AlternativeAuthor | 채인호 | - |
dc.contributor.AlternativeAuthor | 최동주 | - |
dc.contributor.AlternativeAuthor | 김효수 | - |
dc.contributor.AlternativeAuthor | 이명묵 | - |
dc.contributor.AlternativeAuthor | 오병희 | - |
dc.contributor.AlternativeAuthor | 박영배 | - |
dc.contributor.AlternativeAuthor | 최윤식 | - |
dc.contributor.AlternativeAuthor | 택승재 | - |
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