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Intracoronary continuous adenosine infusion

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dc.contributor.authorKoo, Bon-Kwon-
dc.contributor.authorKim, Cheol-Ho-
dc.contributor.authorNa, Sang-Hun-
dc.contributor.authorYoun, Tae-Jin-
dc.contributor.authorChae, In-Ho-
dc.contributor.authorChoi, Dong-Ju-
dc.contributor.authorKim, Hyo-Soo-
dc.contributor.authorLee, Myoung-Mook-
dc.contributor.authorOh, Byung-Hee-
dc.contributor.authorPark, Young-Bae-
dc.contributor.authorChoi, Yun-Shik-
dc.contributor.authorTahk, Seung-Jae-
dc.date.accessioned2010-07-07T23:40:22Z-
dc.date.available2010-07-07T23:40:22Z-
dc.date.issued2005-07-26-
dc.identifier.citationCirc J. 2005;69(8): 908-912en
dc.identifier.issn1346-9843 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16041158-
dc.identifier.urihttps://hdl.handle.net/10371/68475-
dc.description.abstractBACKGROUND: Various methods are used to induce maximal hyperemia for physiologic studies, but the feasibility and efficacy of continuous intracoronary (IC) infusion of adenosine for measurement of fractional flow reserve (FFR) has not been well-defined. METHODS AND RESULTS: Patients with intermediate coronary artery stenosis were consecutively enrolled. In the phase I study, FFR was measured after 3 dosages of IC adenosine infusion (180, 240 and 300 microg/min) in 30 patients. The phase II study was performed to compare the hyperemic efficacy of IC infusion (240 microg/min) with IC bolus injection (40, 80 microg) and intravenous (IV) infusion (140 microg x kg (-1) x min(-1)) of adenosine in 20 patients. In the phase I study, no significant differences in FFR were observed with the 3 different doses of IC infusion (p = 0.06). In the phase II study, FFR after an IC bolus injection (0.83+/-0.06) was significantly higher than with IV (0.79+/-0.07) or IC (0.78+/-0.09) infusion (p < 0.01). However, no difference in FFR was observed for IC and IV infusions. CONCLUSION: IC infusion of adenosine seems to be a safe and effective method of inducing maximal hyperemia for FFR measurement.en
dc.language.isoenen
dc.publisherThe Japanese Circulation Societyen
dc.subjectAdenosine/*administration & dosageen
dc.subjectAgeden
dc.subjectBlood Flow Velocity/drug effectsen
dc.subjectCoronary Circulation/*drug effectsen
dc.subject*Coronary Stenosis/drug therapyen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectHyperemia/*chemically induceden
dc.subjectInfusions, Intra-Arterialen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.titleIntracoronary continuous adenosine infusionen
dc.typeArticleen
dc.contributor.AlternativeAuthor구본권-
dc.contributor.AlternativeAuthor김철호-
dc.contributor.AlternativeAuthor나상훈-
dc.contributor.AlternativeAuthor윤태진-
dc.contributor.AlternativeAuthor채인호-
dc.contributor.AlternativeAuthor최동주-
dc.contributor.AlternativeAuthor김효수-
dc.contributor.AlternativeAuthor이명묵-
dc.contributor.AlternativeAuthor오병희-
dc.contributor.AlternativeAuthor박영배-
dc.contributor.AlternativeAuthor최윤식-
dc.contributor.AlternativeAuthor택승재-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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