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Calcium Hydroxide Inactivates Lipoteichoic Acid from Enterococcus faecalis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Baik, Jung Eun | - |
dc.contributor.author | Kum, Kee-Yeon | - |
dc.contributor.author | Yun, Cheol-Heui | - |
dc.contributor.author | Lee, Jin-Kyung | - |
dc.contributor.author | Lee, Kangseok | - |
dc.contributor.author | Kim, Kack Kyun | - |
dc.contributor.author | Han, Seung Hyun | - |
dc.date.accessioned | 2010-07-12T05:52:48Z | - |
dc.date.available | 2010-07-12T05:52:48Z | - |
dc.date.issued | 2008-11 | - |
dc.identifier.citation | J Endod. 2008;34(11):1355-1359 | en |
dc.identifier.issn | 0099-2399 | - |
dc.identifier.uri | https://hdl.handle.net/10371/68597 | - |
dc.description.abstract | Calcium hydroxide is a widely used endodontic medicament for eliminating viable bacteria and inactivating virulence factors. Enterococcus faecalis, a pathogenic gram-positive bacterium, has been associated with refractory apical periodontitis. Because lipoteichoic acid (LTA) is a major virulence factor of gram-positive bacteria, we examined whether calcium hydroxide could detoxify LTA from E. faecalis. An enzyme-linked immunosorbent assay showed that calcium hydroxide–killed E. faecalis was less potent than heat-killed bacteria in stimulating the release of tumor necrosis factor–α by a murine macrophage line, RAW 264.7 (P < 0.05). Pretreatment of LTA with calcium hydroxide remarkably abrogated the ability of LTA to induce the release of tumor necrosis factor–α (P < 0.05). Furthermore, calcium hydroxide–treated LTA was not able to stimulate Toll-like receptor 2, which recognizes functionally intact LTA. These results suggest that calcium hydroxide could detoxify LTA, resulting in attenuation of the inflammatory responses to E. faecalis and its LTA. | en |
dc.description.sponsorship | This work was supported by the Korea Research Foundation Grant funded by the Korean Government (MOEHRD) (KRF-2007-314-E00186) and by a grant (03-2007-0090) from the Seoul National University Dental Hospital Research Fund, Republic of Korea. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Apical periodontitis | en |
dc.subject | calcium hydroxide | en |
dc.subject | endodontic medicament | en |
dc.subject | Enterococcus faecalis | en |
dc.subject | lipoteichoic acid | en |
dc.subject | Toll-like receptor 2 | en |
dc.title | Calcium Hydroxide Inactivates Lipoteichoic Acid from Enterococcus faecalis | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 백정은 | - |
dc.contributor.AlternativeAuthor | 금기연 | - |
dc.contributor.AlternativeAuthor | 윤철희 | - |
dc.contributor.AlternativeAuthor | 이진경 | - |
dc.contributor.AlternativeAuthor | 이강석 | - |
dc.contributor.AlternativeAuthor | 김각균 | - |
dc.contributor.AlternativeAuthor | 한승현 | - |
dc.identifier.doi | 10.1016/j.joen.2008.08.014 | - |
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