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Antimicrobial Efficacy of a Polymeric Chlorhexidine Release Device Using In Vitro Model of Enterococcus faecalis Dentinal Tubule Infection

Cited 29 time in Web of Science Cited 37 time in Scopus
Authors
Lee, Yoon; Han, Seung Hyun; Hong, Sang-Hee; Lee, Jin-Kyung; Ji, Hye; Kum, Kee-Yeon
Issue Date
2008-07
Publisher
Elsevier
Citation
Journal of Endodontics 2008;34(7):855-858
Keywords
Antimicrobial efficacycylindrical dentin blockEnterococcus faecalisoptical densitypolymeric chlorhexidine-controlled release device
Abstract
This study aimed to assess the antimicrobial efficacy of a novel polymeric chlorhexidine-controlled release device as an intracanal medicament. One hundred cylindrical dentin blocks prepared from human single-rooted teeth were inoculated with Enterococcus faecalis for 3 weeks. The intracanal medicaments tested were calcium hydroxide, a polymeric chlorhexidine-controlled release device (PCRD), a polymeric controlled release device without chlorhexidine (CHx), 0.2% CHx solution, and sterile saline. Dentin samples (at 200-μm and 400-μm depths) were collected from the medicated canal lumens after 1 week of medication with sterile LightSpeed files and placed in growth medium. Bacterial growth was assessed spectrophotometrically by analysis of optical density (OD) after 24 hours of incubation. The OD values at both depths were significantly lower in the PCRD group than in the other experimental groups (P < .001). These results indicate that a PCRD can be an effective intracanal medicament against E. faecalis.
ISSN
0099-2399
Language
English
URI
http://hdl.handle.net/10371/68665
DOI
https://doi.org/10.1016/j.joen.2008.04.008
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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