Browse

Expression of UNCL during development of periodontaltissue and response of periodontal ligament fibroblaststo mechanical stress in vivo and in vitro

Cited 8 time in Web of Science Cited 9 time in Scopus
Authors
Park, Joo-Cheol; Kim, Heung-Joong; Choi, Yong Seok; Jeong, Moon-Jin; Kim, Byung-Ock; Lim, Sung-Hoon; Kim, Do Kyung; Kim, Chong Kwan
Issue Date
2007-01
Publisher
Springer Verlag
Citation
Cell and Tissue Research 327:25-31
Keywords
UNCLPeriodontal ligamentFibroblastMechanical stressCementoblastDifferentiationHumanRat (Sprague-Dawley)
Abstract
Mutations in two genes, uncoordinated (unc) and uncoordinated-like (uncl), lead to a failure of mechanotransduction in Drosophila. UNCL, the human homolog of unc and uncl, is preferentially expressed in periodontal ligament (PDL) fibroblasts compared with gingival fibroblasts. However, the precise role of UNCL in the PDL remains unclear. The aim of the present study has been to examine whether mechanical stimuli modulate the expression of UNCL in the human PDL in vivo and in vitro and to examine the roles of UNCL in the development, regeneration, and repair of the PDL. We have investigated the expression pattern of UNCL during the development of periodontal tissue and the response of PDL fibroblasts to mechanical stress in vivo and in vitro. The expression of UNCL mRNA and protein increases with PDL fibroblast differentiation from the confluent to multilayer stage but slightly decreases on mineralized nodule formation. UNCL has also been localized in ameloblasts and adjacent cells, differentiating cementoblasts, and osteoblasts of the developing tooth. Strong distinct UNCL expression has further been observed in the differentiating cementoblasts of the tooth periodontium at the site of tension after orthodontic tooth movement. Application of cyclic mechanical stress on PDL fibroblasts increases the expression of UNCL mRNA. These results indicate that UNCL plays important roles in the development, differentiation, and maintenance of periodontal tissues and also suggest a potential role of UNCL in the mechanotransduction of PDL fibroblasts.
ISSN
0302-766X
Language
English
URI
https://hdl.handle.net/10371/68679
DOI
https://doi.org/10.1007/s00441-006-0304-3
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse