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In vitro degradation behaviour of non-porous ultra-finepoly(glycolic acid)/poly(L-lactic acid) fibres and porousultra-fine poly(glycolic acid) fibres

Cited 71 time in Web of Science Cited 82 time in Scopus
Issue Date
2005-12
Publisher
Elsevier
Citation
Polymer Degradation and Stability 2005;90:441-448
Keywords
poly(glycolic acid)poly(ㄴ-lactic acid)electrospinningporous ultra fine fibrebiodegradability
Abstract
The in vitro degradation behaviour of non-porous ultra-fine poly(glycolic acid)/poly(l-lactic acid) (PGA/PLA) fibres and porous ultra-fine PGA fibres was investigated. The non-porous ultra-fine PGA/PLA fibres were prepared by electrospinning of a PGA/PLA solution in 1,1,1,3,3,3-hexafluoro-2-propanol and the porous ultra-fine PGA fibres were obtained from them via selective removal of PLA with chloroform. Since PLA has a lower degradation rate than PGA, the degradation rates of the ultra-fine PGA/PLA fibres decreased with increasing content of PLA. The porous ultra-fine PGA fibres were degraded in vitro in the order of non-porous PGA > P-PGA/PLA(90/10) > P-PGA/PLA(70/30) > P-PGA/PLA(50/50) > P-PGA/PLA(30/70) due to autocatalytic hydrolysis.
ISSN
0141-3910
Language
English
URI
https://hdl.handle.net/10371/68697
DOI
https://doi.org/10.1016/j.polymdegradstab.2005.04.015
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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