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Ternary complex with Trk, p75, and an ankyrin-rich membrane spanning protein.

Cited 45 time in Web of Science Cited 45 time in Scopus
Authors
Chang, Mi-Sook; Arevalo, Juan Carlos; Chao, Moses V
Issue Date
2004-10
Publisher
Wiley-Liss
Citation
Journal of Neuroscience Research Vol.78 No.2, pp. 186-192
Keywords
NGFneurotrophinreceptor complex
Abstract
Neurotrophins play many critical roles in regulating neuronal plasticity, survival, and differentiation in the nervous system. Neurotrophins recognize two different receptors, the Trk receptor tyrosine kinase and the p75 neurotrophin receptor, which are associated closely. Several adaptor proteins are associated with each receptor. An ankyrin-rich membrane spanning protein (ARMS), originally identified as a substrate for protein kinase D (Kidins220) and as a p75 interacting protein, serves as a novel downstream target of Trk receptor tyrosine kinases. Kidins220/ARMS is co-expressed frequently with Trk and p75 and represents the only membrane-associated protein known to interact with both receptors. We report here that a ternary complex can be formed between Trk, p75, and Kidins220/ARMS. The extracellular domains of the TrkA and the p75 receptors are necessary for their association, whereas the juxtamembrane region of p75 was responsible for the interaction with Kidins220/ARMS. Interestingly, increasing the level of Kidins220/ARMS expression resulted in a decreased association of TrkA with p75. These findings thus suggest that Kidins220/ARMS plays an important role in regulating interactions between Trk and p75 neurotrophin receptors.
ISSN
0360-4012
Language
English
URI
https://hdl.handle.net/10371/68700
DOI
https://doi.org/10.1002/jnr.20262

https://doi.org/10.1002/jnr.20262
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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