Design of a Mini-Bioreactor System with Stimulating Devices for Cell Culture in Tissue Engineering (1)

Abstract

This study has investigated the design of a mini-bioreactor system with bio-stimuli for culturing cells and tissue in tissue engineering. The present study in this paper was to review the several bioreactor systems related to cells culture in tissue engineering especially and to design a novel bioreactor system with bio-stimuli consisting of cell culture catridge and stimulating devices such as ultrasound and electrical stimuli. A bioreactor system is the general term applied to a closed culture environment, that is usually mixed, that enables control of one or more enviornmental or operating variables that affect biological processes (Asenjo and Merchuk 1995). In biotechnology, the use of a bioreactors is to grow mammalian cells to high cell densities in order to produce a metabolic product and enzyme. In these applications of several bioreactor systems, the most common bioreactors applied to the batch stirred tank reactor as well as continuous stirred tank reactors, packed beds, and membrane bioreactors (Asenjo an Merchuk 1995).