S-Space College of Dentistry/School of Dentistry (치과대학/치의학대학원) Dept. of Dentistry (치의학과) Journal Papers (저널논문_치의학과)
High levels of soluble herpes virus entry mediator in sera of patients with allergic and autoimmune diseases
- Kim, Kack Kyun; Jung, Hyo Won; La, Su Jin; Kim, Ji Young; Heo, Suk Kyeung; Kim, Ju Yang; Wang, Sa; Lee, Ki Man; Cho, Hong Rae; Lee, Hyeon Woo; Kwon, Byungsuk; Kim, Byung Sam; Kwon, ByoungSe
- Issue Date
- Korean Society of Medical Biochemistry
- Experimental and Molecular Medicine 2003;35:501-508
- asthma; atopic; autoimmune diseases; dermatitis; inflammation mediators; rheumatoid arthritis; tumor necrosis factor
- Herpes virus entry mediator (HVEM) is a newly discovered member of the tumor necrosis factor receptor (TNFR) superfamily that has a role in herpes simplex virus entry, in T cell activation and in tumor immunity. We generated mAb against HVEM and detected soluble HVEM (SHVEM) in the sera of patients with various autoimmune diseases. HVEM was constitutively expressed on CD4(+) and CD8(+) T cells, CD19(+) B cells, CD14(+) monocytes, neutrophils and dendritic cells. In three-way MLR, mAb 122 and 139 were agonists and mAb 108 had blocking activity. An ELISA was developed to detect sHVEM in patient sera. sHVEM levels were elevated in sera of patients with allergic asthma, atopic dermatitis and rheumatoid arthritis. The mAbs discussed here may be useful for studies of the role of HVEM in immune responses. Detection of soluble HVEM might have diagnostic and prognostic value in certain immunological disorders.