고체상 펩타이드 합성을 위한 단분산, 다공성 Core-Shell Type 고분자 지지체의 합성 및 특성분석

Abstract

Due to recent development of solid-phase organic synthesis and micro techniques with beads, the need for micron-size core-shell type resin with a narrow size distribution is demanding. Monodisperse and porous core-shell type resins with a highly cross-linked polystyrene core and a poly(ethylene glycol) (PEG) shell were prepared by seeded emulsion polymerization. For this, a new PEG-macromonomer which has long alkyl chain was prepared from 2-chlorotrityl chloride resins as a polymerizable surfactant and a stabilizer in order to get monodispersed and porous resins in the seeded emulsion polymerization system. The new resin was prepared by co-polymerization of styrene and a polymerizable PEG macromer, mono-N-methacryloyl- aminoundecanoyl Jeffamine 500. The new resins have all of the functional groups at the outer shell of the bead. The new resins are monodispersed beads with ca. 17㎛ in diameter. The resins were characterized by SEM, BET, Size Distribution Analyzer, Confocal Laser Scanning Microscope.