S-Space College of Engineering/Engineering Practice School (공과대학/대학원) Dept. of Chemical and Biological Engineering (화학생물공학부) Theses (Master's Degree_화학생물공학부)
의약품 원료의 회분식 냉각 결정화 공정에서 접종 효과
- Issue Date
- 서울대학교 대학원
- 냉각 제어 프로그램; Programmed cooling; 형상; Morphology; 접종 온도; Seeding temperature; 접종 양; Seed amound; 평균크기; Mean seze
- 학위논문(석사)--서울대학교 대학원 :응용화학부,2003.
- In the present study a batch cooling crystallization of a pharmaceutical compound
designated CPD03 was investigated. To improve the present process, we considered
the effect of the seeding temperature and seed amount on CPD03 crystal quality
following the programmed cooling curve. To do this, the solubility of CPD02 which
is raw material of the present process in IPA/water solvent was measured and the
crystallization temperature at various cooling rates was measured. As a result, a
metastable zone width and the proper seeding temperature was obtained. And the
programmed cooling function with each seeding temperature was calculated.
The present experimental result shows that with increasing seeding temperature in
metastable zone the mean size of product crystal was increased. This means that a
higher seeding temperature brings the less number of nucles because of the lower
supersaturation. Also, the effect of seed amount on the product crystal quality was
investigated. As a result , the optimum seed amount was obtained.
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