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Salivary levels of IL-1 beta, IL-6, IL-8, and TNF-alpha in patients with burning mouth syndrome

Cited 46 time in Web of Science Cited 51 time in Scopus
Authors
Kho, Hong-Seop; Suh, Kyung-Im; Kim, Young-Ku
Issue Date
2009-09
Publisher
Elsevier
Citation
Archives of Oral Biology 2009;54:797-802
Keywords
BMSSalivaCytokineBlood contamination
Abstract
Objective
To compare salivary IL-1β, IL-6, IL-8, and TNF-α levels between patients with burning mouth syndrome (BMS) and controls.

Design
Forty female patients with BMS (mean age: 61.6 ± 10.1 years) and 20 female control subjects (mean age: 65.1 ± 9.0 years) were included in the study. Unstimulated (UWS) and stimulated whole saliva samples (SWS) were collected and their flow rates were determined. Salivary IL-1β, IL-6, IL-8, and TNF-α levels and total protein concentration were also determined. Salivary transferrin level was determined to investigate the level of blood contamination in saliva samples. Gingival index of the subjects was also examined. Student's t-test, Pearson's correlation analysis, and analysis of covariance were used.

Results
No significant differences were found in the salivary levels of IL-1β, IL-6, IL-8, and TNF-α in BMS patients compared with controls. Salivary flow rates and their total protein concentrations did not differ significantly between the groups. The levels of salivary cytokines and total protein concentration correlated significantly with the level of blood contamination in both UWS and SWS.

Conclusion
There were no differences in the salivary levels of IL-1β, IL-6, IL-8, and TNF-α in BMS patients compared with controls. Cytokine levels in whole saliva were affected mainly by the amount of blood contamination.
ISSN
0003-9969
Language
English
URI
https://hdl.handle.net/10371/68964
DOI
https://doi.org/10.1016/j.archoralbio.2009.05.007
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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