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Induction of human umbilical cord blood-derived stem cells with embryonic stem cell phenotypes into insulin producing islet-like structure

Cited 77 time in Web of Science Cited 90 time in Scopus
Authors
Sun, Bo; Roh, Kyung-Hwan; Lee, Sae-Rom; Lee, Yong Soon; Kang, Kyung-Sun
Issue Date
2007-01-24
Publisher
Elsevier
Citation
Biochem Biophys Res Commun 354 (2007) 919-923
Keywords
Stem cellsHuman umbilical cord bloodIslet-like structure differentiationInsulin producing cells
Abstract
Success in islet-transplantation-based therapies for type I diabetes, coupled with a worldwide shortage of transplant-ready islets, has motivated efforts to develop renewable sources of islet-replacement tissue. Embryonic stem cells (ESCs) have been successfully induced into insulin producing islet-like structure in several studies. However, the source of the ESCs has presented ethical and technical concerns. Here, we isolated a population of stem cells from human cord blood (UCB), which expressed embryo stage specific maker, SSEA-4, and the multi-potential stem cell marker, Oct4. Subsequently, we successfully induced them into insulin-producing islet-like structures, which co-express insulin and C-peptide. These findings might have a significant potential to advance human UCB derived stem-cell-based therapeutics for diabetes.
ISSN
0006-291X
Language
English
URI
https://hdl.handle.net/10371/6957
DOI
https://doi.org/10.1016/j.bbrc.2007.01.069
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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