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Susceptibility of Various Oral Bacteria to Antimicrobial Peptides and to Pagosytosis by Nutrophils.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ji, S | - |
dc.contributor.author | Hyun, J | - |
dc.contributor.author | Park, E | - |
dc.contributor.author | Lee, B.-L | - |
dc.contributor.author | Kim, K.-K | - |
dc.contributor.author | Choi, Y | - |
dc.date.accessioned | 2010-09-02T07:25:38Z | - |
dc.date.available | 2010-09-02T07:25:38Z | - |
dc.date.issued | 2007-03 | - |
dc.identifier.citation | Journal of Periodontal Research 2007;42:410-419 | en |
dc.identifier.issn | 0022-3484 | - |
dc.identifier.uri | https://hdl.handle.net/10371/69592 | - |
dc.description.abstract | Background and Objective: The aim of this study was to compare the susceptibility of nonperiodontopathic and periodontopathic bacteria to major defense mechanisms for bacterial clearance in gingival sulcus.
Material and Methods: Twenty strains of 13 oral bacterial species were studied for their susceptibility to phagocytosis by human neutrophils and to the antimicrobial peptides LL-37 and human beta defensin-3. The minimum inhibitory concentrations of LL-37 and human beta defensin-3 were determined by a liquid dilution assay, and susceptibility to phagocytosis was examined by a flow cytometric phagocytosis assay. Results: The minimum inhibitory concentrations of LL-37 and human beta defensin-3 varied greatly, depending on the strain and species. Although a significant difference between the non- and periodontopathic groups was not observed, the red-complex bacteria were more resistant to LL-37 than the others (p = 0.004). The susceptibility of oral bacteria to phagocytosis was quite variable, depending on the species but not on the strains. The periodontopathic bacteria, especially Actinobacillus actinomycetemcomitans and the red-complex triad, were more resistant to phagocytosis than were the nonperiodontopathic bacteria (p = 0.0003). In addition, bacteria resistant both to antimicrobial peptides and to phagocytosis were more common in the periodontopathic group. Conclusion: Our results indicate that immune evasion may contribute to the pathogenicity of some periodontopathic bacteria. | en |
dc.description.sponsorship | This work was supported by a research
fund to Suk Ji from the Education and Cultural Foundation of College of Dentistry, Chosun University (2006) and by a Korea Research Foundation Grant KRF-2003-E00255 to Youngnim Choi, funded by the Korean Government. | en |
dc.language.iso | en | en |
dc.publisher | Wiley-Blackwell | en |
dc.subject | antimicrobial peptide | en |
dc.subject | oral bacteria | en |
dc.subject | phagocytosis | en |
dc.subject | susceptibility | en |
dc.title | Susceptibility of Various Oral Bacteria to Antimicrobial Peptides and to Pagosytosis by Nutrophils. | en |
dc.type | Article | en |
dc.identifier.doi | 10.1111/j.1600-0765.2006.00962.x | - |
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