Publications
Detailed Information
Apatite-mineralized polycaprolactone nanofibrous web as a bone tissue regeneration substrate.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yu, Hye-Sun | - |
dc.contributor.author | Jang, Jun-Hyeog | - |
dc.contributor.author | Kim, Tae-Il | - |
dc.contributor.author | Lee, Hae-Hyoung | - |
dc.contributor.author | Kim, Hae-Won | - |
dc.date.accessioned | 2010-09-03 | - |
dc.date.available | 2010-09-03 | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | Journal of Biomedical Materials Research Part A, 2009;88A(3):747-754 | en |
dc.identifier.issn | 1549-3296 | - |
dc.identifier.uri | https://hdl.handle.net/10371/69605 | - |
dc.description.abstract | Degradable synthetic polymers with a nanofibrous
structure have shown great promise in populating and recruiting cells for the reconstruction of damaged tissues. However, poor cell affinity and lack of bioactivity have limited their potential usefulness in bone regeneration. We produced polymeric nanofiber poly(e-caprolactone) (PCL) with its surface mineralized with bone-like apatite for use as bone regenerative and tissue engineering matrices. PCL was first electrospun into a nanofibrous web, and the surface was further mineralized with apatite following a series of solution treatments. The surface of the mineralized PCL nanofiber was observed to be almost fully covered with nanocrystalline apatites. Through mineralization, the wettability of the nanofiber matrix was greatly improved. Moreover, the murine-derived osteoblastic cells were shown to attach and grow actively on the apatite-mineralized nanofibrous substrate. In particular, the mineralized PCL nanofibrous substrate significantly stimulated the expression of bone-associated genes, including Runx2, collagen type I, alkaline phosphatase, and osteocalcin, when compared with the pure PCL nanofiber substrate without mineralization. The currently developed polymer nanofibrous web with the bioactive mineralized surface is considered to be potentially useful as bone regenerative and tissue engineering matrices. | en |
dc.language.iso | en | en |
dc.publisher | Wiley-Blackwell | en |
dc.subject | nanofiber substrate | en |
dc.subject | electrospinning | en |
dc.subject | apatite mineralization | en |
dc.subject | bone regeneration matrix | en |
dc.subject | osteoblast responses | en |
dc.title | Apatite-mineralized polycaprolactone nanofibrous web as a bone tissue regeneration substrate. | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 유혜선 | - |
dc.contributor.AlternativeAuthor | 장준형 | - |
dc.contributor.AlternativeAuthor | 김태일 | - |
dc.contributor.AlternativeAuthor | 이해형 | - |
dc.contributor.AlternativeAuthor | 김해원 | - |
dc.identifier.doi | 10.1002/jbm.a.31709 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.