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Establishment of a canine spinal cord injury model induced by epidural balloon compression

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dc.contributor.authorLim, Ji-Hey-
dc.contributor.authorJung, Chang-Su-
dc.contributor.authorByeon, Ye-Eun-
dc.contributor.authorKim, Wan Hee-
dc.contributor.authorYoon, Junghee-
dc.contributor.authorKang, Kyung-Sun-
dc.contributor.authorKweon, Oh Kyeong-
dc.date.accessioned2009-08-11T22:39:35Z-
dc.date.available2009-08-11T22:39:35Z-
dc.date.issued2007-
dc.identifier.citationJ Vet Sci 2007, 8, 89-94en
dc.identifier.issn1229-845X-
dc.identifier.urihttp://www.vetsci.org/2007/abstract/89a.html-
dc.identifier.urihttps://hdl.handle.net/10371/6961-
dc.description.abstractA model that provides reproducible, submaximal yet sufficient spinal cord injury is needed to allow experiments leading to development of therapeutic techniques and prediction of clinical outcome to be conducted. This study describes an experimental model for spinal cord injury that uses three different volumes of balloon inflation and durations of compression to create a controlled gradation outcome in adult dogs. Twenty-seven mongrel dogs were used for this study. A 3-french embolectomy catheter was inserted into the epidural space through a left hemilaminectomy hole at the L4 vertebral arch. Balloons were then inflated with 50, 100, or 150 μl of a contrast agent at the L1 level for 6, 12, or 24 h and spinal canal occlusion (SCO) measured using computed tomography. Olby score was used to evaluate the extent of spinal cord injury and a histopathologic examination was conducted 1 week after surgery. The SCO of the 50, 100, and 150 μl inflations was 22-46%, 51-70%, and 75-89%, respectively (p < 0.05). Olby scores were diminished significantly by a combination of the level of SCO and duration of inflation in all groups. Olby scores in the groups of 150 μl-12 h, 150 μl-24 h, and 100 μl-24 h were 0.5, 0, and 1.7, respectively. Based on these results, a SCO > 50% for 24 h, and > 75% for 12 h induces paraplegia up to a week after spinal cord injury.en
dc.description.sponsorshipThis work was supported by the BK21 Program for
Veterinary Science and Seoul R&BD Program (10548).
en
dc.language.isoen-
dc.publisher대한수의학회 = The Korean Society of Veterinary Scienceen
dc.subjectdogen
dc.subjectballoon catheteren
dc.subjectspinal cord compression injuryen
dc.subjectspinal cord occlusionen
dc.titleEstablishment of a canine spinal cord injury model induced by epidural balloon compressionen
dc.typeArticleen
dc.contributor.AlternativeAuthor임지혜-
dc.contributor.AlternativeAuthor정창수-
dc.contributor.AlternativeAuthor변예은-
dc.contributor.AlternativeAuthor김완희-
dc.contributor.AlternativeAuthor윤정희-
dc.contributor.AlternativeAuthor강경선-
dc.contributor.AlternativeAuthor권오경-
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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