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Transforming growth factor-alpha and oral fibroma: Immunohistochemical and in situ hybridization study.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Rotaru, Horatiu | - |
dc.contributor.author | Choi, Je-Yong | - |
dc.contributor.author | Hong, Sam-Pyo | - |
dc.contributor.author | Lee, Yong-Chan | - |
dc.contributor.author | Yun, Kyoung-In | - |
dc.contributor.author | Kim, Seong-Gon | - |
dc.date.accessioned | 2010-09-03T03:59:45Z | - |
dc.date.available | 2010-09-03T03:59:45Z | - |
dc.date.issued | 2003 | - |
dc.identifier.citation | J Oral Maxillofac Surg 61:1449-1454 | en |
dc.identifier.issn | 0304-3940 | - |
dc.identifier.uri | https://hdl.handle.net/10371/69632 | - |
dc.description.abstract | Purpose:
Transforming growth factor-α (TGF-α) is usually expressed in cell lines derived from sarcomas. It is known as a mitogen for fibroblasts. The aim of this study was to determine whether there were any differences in the expression pattern of TGF-α between normal oral mucosa and oral fibroma. Patients and Methods: Fourteen pathologic specimens (6 males and 8 females; 37.2 ± 23.2 years) and 10 normal oral mucosal specimens (5 females and 5 males; 43.8 ± 17.7 years) were used for this study. Identification of TGF-α was sought by using immunohistochemistry and in situ hybridization. Results: The samples from normal oral mucosa did not express TGF-α. One sample from oral fibroma did not express TGF-α (7.1%). Five samples from oral fibroma expressed TGF-α sparsely (35.7%). Eight samples showed diffuse expression of TGF-α (57.1%). The immunopositive reaction to TGF-α in oral fibroma was localized in the basal layer and the fibroblasts that resided beneath the epithelium. This pattern was also shown in the in situ hybridization study as well. Conclusion: TGF-α is expressed in oral fibromas. It suggested that TGF-α might play a role in fibroblast proliferation in oral fibromas. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.title | Transforming growth factor-alpha and oral fibroma: Immunohistochemical and in situ hybridization study. | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 최재용 | - |
dc.contributor.AlternativeAuthor | 홍삼표 | - |
dc.contributor.AlternativeAuthor | 이용찬 | - |
dc.contributor.AlternativeAuthor | 윤경인 | - |
dc.contributor.AlternativeAuthor | 김성곤 | - |
dc.identifier.doi | 10.1016/j.joms.2003.02.001 | - |
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