Browse

Titanium implants and BMP-7 in bone:an experimental model in the rabbit

Cited 27 time in Web of Science Cited 27 time in Scopus
Authors

Stenport, V. Franke; Johansson, C; Heo, S. Joo; Aspenberg, P; Albrektsson, T

Issue Date
2003-03
Publisher
Springer Verlag
Citation
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE. 14 (2003) 247-254
Abstract
This study evaluates the effect of rhBMP-7/OP-1 on the osseointegration of commercially pure titanium implants in an experimental implant model in rabbits. Threaded titanium implants with two transverse parallel canals were inserted in the femur and tibia of rabbits. The canals were filled with, 10 g of BMP-7/collagen carrier, pure collagen carrier or were left empty as a control. The stiffness of the implant fixation was evaluated by Resonance Frequency Analysis (RFA) at baseline and four weeks postoperativly. Percentage of bone ingrowth in the canals was measured on microradiographs. Histomorphometry along the threaded part of the implants was performed on 15 m thin sections. The results from the RFA demonstrated a higher mean value for the BMP-7 treated implants in the tibia than the carrier treated implants but not compared to the control implants. The control implants in the tibia demonstrated more bone ingrowth in the upper canal than to the carrier or the BMP-7 treated implants. Apart from these differences there were no significant effects of BMP. In this study BMP-7 did not contribute to any substantially improved bone anchorage of titanium implants.
ISSN
0957-4530
Language
English
URI
https://hdl.handle.net/10371/69668
DOI
https://doi.org/10.1023/A:1022884724059
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse