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Toll-like receptor 2 contributes to glial cell activation and heme oxygenase-1 expression in traumatic brain injury
DC Field | Value | Language |
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dc.contributor.author | Park, Chanhee | - |
dc.contributor.author | Cho, Ik-Hyun | - |
dc.contributor.author | Kim, Donghoon | - |
dc.contributor.author | Jo, Eun-Kyeong | - |
dc.contributor.author | Choi, Se-Young | - |
dc.contributor.author | Oh, Seog Bae | - |
dc.contributor.author | Park, Kyoungpyo | - |
dc.contributor.author | Kim, Joong Soo | - |
dc.contributor.author | Lee, Sung Joong | - |
dc.date.accessioned | 2010-09-05T23:16:56Z | - |
dc.date.available | 2010-09-05T23:16:56Z | - |
dc.date.issued | 2008-01 | - |
dc.identifier.citation | Neuroscience Letters 431 (2007) 123-128 | en |
dc.identifier.issn | 0304-3940 | - |
dc.identifier.uri | https://hdl.handle.net/10371/69690 | - |
dc.description.abstract | Traumatic brain injury is accompanied by glial cell activation around the site of the injury. In this study, we investigated the role of toll-like receptor 2 (TLR2) in glial cell activation using a stab-wound injury (SWI) model with TLR2 knock-out mice. Penetration of a normal mouse brain with a 26-G needle using a stereotaxic instrument resulted in an 18- and 4-fold upregulation of GFAP and CD11b mRNA, respectively, along the needle track in the injury area. However, in the TLR2 knock-out mice, the induced expression of these genes was reduced by 70% and 40%, respectively. Likewise, there was a reduction in the area of activated glial cells detected by immunohistochemistry and the glial cells had a less-activated morphology in the TLR2 knock-out mice. In addition, the expression of the heme oxygenase-1 (HO-1) gene, a glia-expressing wound-responsive gene, was reduced after SWI in TLR2 knock-out mice. Taken together, these data argue that TLR2 contributes to the glial cell activation and HO-1 gene expression associated with traumatic brain injury. | en |
dc.description.sponsorship | This work was supported by the Neurobiology Research
Program at the Korea Ministry of Science and Technology (M10412000014-07N1200-01410), the Korea Science and Engineering Foundation (KOSEF) grant funded by the Korea government (MOST) (R01-2007-000-10243-0), and by a Korea Research Foundation grant (KRF-2005-070-C00096). | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Toll-like receptor 2 | en |
dc.subject | Heme oxygenase-1 | en |
dc.subject | Glial activation | en |
dc.subject | Stab-wound injury | en |
dc.title | Toll-like receptor 2 contributes to glial cell activation and heme oxygenase-1 expression in traumatic brain injury | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 박찬희 | - |
dc.contributor.AlternativeAuthor | 조익현 | - |
dc.contributor.AlternativeAuthor | 김동훈 | - |
dc.contributor.AlternativeAuthor | 조윤경 | - |
dc.contributor.AlternativeAuthor | 최세영 | - |
dc.contributor.AlternativeAuthor | 오석배 | - |
dc.contributor.AlternativeAuthor | 박경표 | - |
dc.contributor.AlternativeAuthor | 김종수 | - |
dc.contributor.AlternativeAuthor | 이성종 | - |
dc.identifier.doi | 10.1016/j.neulet.2007.11.057 | - |
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