S-Space College of Dentistry/School of Dentistry (치과대학/치의학대학원) Dept. of Dentistry (치의학과) Journal Papers (저널논문_치의학과)
Preferential expression of L-type amino acid transporter 1 in ameloblasts during rat tooth development
- Park, J.-C; Kim, Y.B; Yoon, J.H; Kim, H.-J; Kim, S.M; Kanai, Y; Endou, H; Kim, D.K
- Issue Date
- Anat. Histol. Embryol. 33, 119-124
- Certain amino acid transport systems play an important role in supplying organic nutrients to each cell and for cell proliferation during tooth development. However, the mechanisms responsible for such actions are unclear. This study demonstrated for the first time that LAT1 and 4F2hc are expressed during tooth development in prenatal and postnatal rats, and that the transporters show cell-specific expression in ameloblasts, which are the epithelium-derived dental cells. LAT1 and 4F2hc expression was not observed in other dental cells of the developing teeth such as odontoblasts and cementoblasts. Overall, these results suggest that LAT1 and 4F2hc might play an important role in enamel formation. [ABSTRACT FROM AUTHOR]
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