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Transplantation of mesenchymal stem cells is an optimal approach for plastic surgery

Cited 58 time in Web of Science Cited 59 time in Scopus
Authors
Fang, Dianji; Seo, Byoung-Moo; Sonoyama, Wataru; Yamaza, Takayoshi; Zhang, Chunmei; Wang, Songlin; Shi, Songtao
Issue Date
2006-12
Publisher
AlphaMed Press
Citation
STEM CELLS 2007;25:1021-1028
Keywords
Bone marrow mesenchymal stem cellsPeriodontal ligament stem cellsTissue regenerationPlastic surgery
Abstract
Mesenchymal stem cells (MSCs) are able to differentiate into a variety of cell types, offering promising approaches for stem cell-mediated tissue regeneration. Here, we explored the potential of utilizing MSCs to reconstruct orofacial tissue, thereby altering the orofacial appearance. We demonstrated that bone marrow MSCs were capable of generating bone structures and bone-associated marrow elements on the surfaces of the orofacial bone. This resulted in significant recontouring of the facial appearance in mouse and swine. Notably, the newly formed bone and associated marrow tissues integrated with the surfaces of the recipient bones and re-established a functional bone marrow organ-like system. These data suggested that MSC-mediated tissue regeneration led to a body structure extension, with the re-establishment of all functional components necessary for maintaining the bone and associated marrow organ. In addition, we found that the subcutaneous transplantation of another population of MSCs, the human periodontal ligament stem cells (PDLSCs), could form substantial amounts of collagen fibers and improve facial wrinkles in mouse. By contrast, bone marrow MSCs failed to survive at 8 weeks post-transplantation under the conditions used for the PDLSC transplantation. This study suggested that the mutual interactions between donor MSCs and recipient microenvironment determine long-term outcome of the functional tissue regeneration. Disclosure of potential conflicts of interest is found at the end of this article.
Disclosure of potential conflicts of interest is found at the end of this article.
ISSN
1549-4918
Language
English
URI
https://hdl.handle.net/10371/69696
DOI
https://doi.org/10.1634/stemcells.2006-0576
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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