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Tissue levels of matrix metalloproteinases in pulps and periapical lesions

Cited 84 time in Web of Science Cited 86 time in Scopus
Authors
Shin, Su-Jung; Lee, Jae-II; Baek, Seung-Ho; Lim, Sung-Sam
Issue Date
2002-04
Publisher
Elsevier
Citation
Journal of Endodontics 2002;22:313-315
Abstract
The purpose of this study was to evaluate the tissue levels of matrix metalloproteinase (MMP)-1, -2, -3 and their distributions in inflamed human dental pulps and periapical lesions. Samples were subjected to enzyme-linked immunosorbent assay and/or immunohistochemistry by using specific antibodies to MMP-1, -2, and -3. Results from enzyme-linked immunosorbent assay were analyzed by using the Mann-Whitney U test and presented as p values.

The concentrations of MMP-1 in all experimental groups were significantly higher than in the control (p < 0.05). The acute pulpitis and control groups were significant different in terms of their MMP-2 levels (p < 0.05). The concentration of MMP-3 in acute pulpitis was significantly higher than the control and chronic pulpitis groups (p < 0.05). Immunohistochemically, MMP-1 and MMP-3 were localized in the infiltrating neutrophils, macrophages, and extracellular matrix of the acute pulpitis group.

These results suggest that MMPs play an important role in the pulp tissue destruction of acute, inflamed pulp.
ISSN
0099-2399
Language
English
URI
https://hdl.handle.net/10371/69707
DOI
https://doi.org/10.1097/00004770-200204000-00013
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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