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Selenite-induced apoptosis of osteoclasts mediated by the mitochondrial pathway
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Min, Byung-Moo | - |
dc.contributor.author | Chung, Youn Wook | - |
dc.contributor.author | Kim, Tae Soo | - |
dc.contributor.author | Lee, Soo Young | - |
dc.contributor.author | Lee, Seoung Hoon | - |
dc.contributor.author | Choi, Yongwon | - |
dc.contributor.author | Kim, Nacksung | - |
dc.contributor.author | Jeong, Dae-Won | - |
dc.contributor.author | Kim, Ick Young | - |
dc.date.accessioned | 2010-09-06 | - |
dc.date.available | 2010-09-06 | - |
dc.date.issued | 2006-01 | - |
dc.identifier.citation | Toxicology Letters 160,143-150 | en |
dc.identifier.issn | 0378-4274 | - |
dc.identifier.uri | https://hdl.handle.net/10371/69715 | - |
dc.description.abstract | The possible effects of sodium selenite on mature osteoclasts were investigated. Incubation of osteoclast-like cells differentiated from RAW 264.7 cells with sodium selenite induced apoptosis as revealed by morphological changes, internucleosomal DNA fragmentation, and activation of caspase-3. Selenite also induced generation of the superoxide anion and reduced the number of free thiol groups in the osteoclast-like cells, suggestive of a shift to a more oxidizing intracellular environment. In addition, selenite induced protein aggregation by thiol cross-linking, loss of the mitochondrial membrane potential, and cytochrome c release in mitochondria isolated from the osteoclast-like cells. Finally, selenite-induced DNA fragmentation in osteoclasts was inhibited both by cyclosporin A, a blocker of the mitochondrial permeability transition pore, and by DEVD-CHO, a cell-permeable inhibitor of caspase-3. These results thus suggest that selenite induces apoptosis mediated by the mitochondrial pathway in mature osteoclasts. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Selenium | en |
dc.subject | Apoptosis | en |
dc.subject | Osteoclast | en |
dc.subject | Mitochondria | en |
dc.title | Selenite-induced apoptosis of osteoclasts mediated by the mitochondrial pathway | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 민병무 | - |
dc.contributor.AlternativeAuthor | 정영욱 | - |
dc.contributor.AlternativeAuthor | 김태수 | - |
dc.contributor.AlternativeAuthor | 이수영 | - |
dc.contributor.AlternativeAuthor | 이승훈 | - |
dc.contributor.AlternativeAuthor | 최용원 | - |
dc.contributor.AlternativeAuthor | 김낙성 | - |
dc.contributor.AlternativeAuthor | 정대원 | - |
dc.contributor.AlternativeAuthor | 김익영 | - |
dc.identifier.doi | 10.1016/j.toxlet.2005.06.019 | - |
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