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Thickness and microhardness of deciduous tooth enamel with known DLX3 mutation

Cited 7 time in Web of Science Cited 8 time in Scopus
Issue Date
2009-09
Publisher
Elsevier
Citation
Archives of Oral Biology 2009;54:830-834
Keywords
EnamelDLX3ThicknessMicrohardnessMutation
Abstract
Aim
To investigate the thickness and hardness of teeth affected by a 2-bp deletion (c.561_562delCT) in the DLX3 gene.

Methods and materials
Extracted maxillary deciduous second molar was collected from the affected individual at age 12 years 7 months. Samples were sectioned buccolingually after embedding in epoxy resin. We measured the enamel thickness and microhardness and performed an elemental analysis using an electron probe microanalyser.

Results
On average, the hardness of the enamel with a 2-bp deletion in DLX3 was about 53% of normal enamel hardness. The mutant enamel thickness was about half of the thickness of the normal control. The calcium level in the enamel with the 2-bp deletion was slightly decreased, while the magnesium level was slightly increased, in comparison to levels measured for normal teeth.

Conclusion
This study shows that enamel affected by a 2-bp deletion in DLX3 has reduced thickness as well as diminished microhardness. These data may explain the severe attrition and interdental spacing observed in affected individuals.
ISSN
0003-9969
Language
English
URI
https://hdl.handle.net/10371/69718
DOI
https://doi.org/10.1016/j.archoralbio.2009.06.005
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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