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Activation of glia and microglial p38 MAPK in medullary dorsal horn contributes to tactile hypersensitivity following trigeminal sensory nerve injury
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Piao, Zheng Gen | - |
dc.contributor.author | Cho, Ik-Hyun | - |
dc.contributor.author | Park, Chul Kyu | - |
dc.contributor.author | Hong, Jin Pyo | - |
dc.contributor.author | Choi, Se-Young | - |
dc.contributor.author | Lee, Sung Joong | - |
dc.contributor.author | Lee, Seungbok | - |
dc.contributor.author | Park, Kyungpyo | - |
dc.contributor.author | Kim, Joong Soo | - |
dc.contributor.author | Oh, Seog Bae | - |
dc.date.accessioned | 2010-09-06T03:21:04Z | - |
dc.date.available | 2010-09-06T03:21:04Z | - |
dc.date.issued | 2006-04 | - |
dc.identifier.citation | Pain. 2006;121(3):219-231 | en |
dc.identifier.issn | 0304-3959 | - |
dc.identifier.uri | https://hdl.handle.net/10371/69745 | - |
dc.description.abstract | Glial activation is known to contribute to pain hypersensitivity following spinal sensory nerve injury. In this study, we investigated mechanisms by which glial cell activation in medullary dorsal horn (MDH) would contribute to tactile hypersensitivity following inferior alveolar nerve and mental nerve transection (IAMNT). Activation of microglia and astrocytes was monitored at 2 h, 1, 3, 7, 14, 28, and 60 days using immunohistochemical analysis with OX-42 and GFAP antibodies, respectively. Tactile hypersensitivity was significantly increased at 1 day, and this lasted for 28 days after IAMNT. Microglial activation, primarily observed in the superficial laminae of MDH, was initiated at 1 day, maximal at 3 days, and maintained until 14 days after IAMNT. Astrocytic activation was delayed compared to that of microglia, being more profound at 7 and 14 days than at 3 days after IAMNT. Both tactile hypersensitivity and glial activation appeared to gradually reduce and then return to the basal level by 60 days after IAMNT. There was no significant loss of trigeminal ganglion neurons by 28 days following IAMNT, suggesting that degenerative changes in central terminals of primary afferents might not contribute to glial activation. Minocycline, an inhibitor of microglial activation, reduced microglial activation, inhibited p38 mitogen-activated protein kinase (MAPK) activation in microglia, and significantly attenuated the development of pain hypersensitivity in this model. These results suggest that glial activation in MDH plays an important role in the development of neuropathic pain and activation of p38 MAPK in hyperactive microglia contributes to pain hypersensitivity in IAMNT model. | en |
dc.description.sponsorship | This research was supported by grant
(M103KV010009-04K2201-00930) from Brain Research Center of the 21st Century Frontier Research Program funded by the Ministry of Science and Technology and grant (RO1-2004-000-103 84-0) from the Basic Research Program of the Korea Science & Engineering Foundation, Republic of Korea. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | c-Fos | en |
dc.subject | GFAP | en |
dc.subject | Glia | en |
dc.subject | Inferior alveolar nerve | en |
dc.subject | Medullary dorsal horn | en |
dc.subject | Mental nerve | en |
dc.subject | Minocycline | en |
dc.subject | OX-42 | en |
dc.subject | p38 mitogen-activated protein kinase | en |
dc.subject | Tactile hypersensitivity | en |
dc.title | Activation of glia and microglial p38 MAPK in medullary dorsal horn contributes to tactile hypersensitivity following trigeminal sensory nerve injury | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 조익현 | - |
dc.contributor.AlternativeAuthor | 박철규 | - |
dc.contributor.AlternativeAuthor | 홍진표 | - |
dc.contributor.AlternativeAuthor | 최세영 | - |
dc.contributor.AlternativeAuthor | 이성중 | - |
dc.contributor.AlternativeAuthor | 이승복 | - |
dc.contributor.AlternativeAuthor | 박경표 | - |
dc.contributor.AlternativeAuthor | 김중수 | - |
dc.contributor.AlternativeAuthor | 오석배 | - |
dc.identifier.doi | 10.1016/j.pain.2005.12.023 | - |
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