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Genitourinary Rhabdomyosarcoma with Systemic Metastasis in a Young Dog

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dc.contributor.authorBae, I.-H.-
dc.contributor.authorKim, Y.-
dc.contributor.authorParkhrin, B.-
dc.contributor.authorYou, Mi-Hyeon-
dc.contributor.authorHwang, Cheol Yong-
dc.contributor.authorKim, J.-H.-
dc.contributor.authorKim, Dae-Yong-
dc.date.accessioned2009-08-11T22:59:47Z-
dc.date.available2009-08-11T22:59:47Z-
dc.date.issued2007-
dc.identifier.citationVet Pathol 44:518-520, 2007en
dc.identifier.issn0300-9858-
dc.identifier.urihttp://www.vetpathology.org/cgi/content/full/44/4/518-
dc.identifier.urihttps://hdl.handle.net/10371/6975-
dc.description.abstractA 2-year-old intact female Golden Retriever presented due to rapidly progressing depression, ascites, dysuria, abdominal pain, and severe vaginal bleeding. At necropsy, the retroperitoneal space was expanded by multiple coalescing neoplastic nodules and the uterine wall was thickened with poorly defined neoplastic infiltrates. The urinary bladder was markedly thickened due to botryoid nodules exhibiting exophytic growth into the lumen. Metastases to lung, liver, kidney, and abdominal and thoracic lymph nodes were also noted. Microscopically, the genital tract and retroperitoneal masses were consistent with the alveolar subtype of rhabdomysarcoma, while the urinary bladder mass had characteristics of the embryonal subtype. Immunohistochemically, the neoplastic cells in all these tissue sites were intensely positive for desmin, sacromeric actin, and vimentin, while they were uniformly negative for cytokeratin and smooth muscle actin. Phosphotungstic acid hematoxylin stain revealed cross-striations in the cytoplasm of scattered neoplastic cells. Based on the gross findings, histopathology, and immunohistochemistry, genitourinary rhabdomyosarcoma with multisystemic metastases was made.en
dc.description.sponsorshipThis work was supported through the Brain Korea 21 Program for Veterinary Science and by Korean Research Foundation (KRF-2006-005-J02901). The authors thank Dr. Mac Law at North Carolina State University for critical review and comments and Sandra Horton (North Carolina State University) for expertise in staining.en
dc.language.isoenen
dc.publisherAmerican College of Veterinary Pathologistsen
dc.subjectDogsen
dc.subjectrhabdomyosarcomaen
dc.subjectsarcoma botryoidesen
dc.subjecturinary bladderen
dc.subjectuterusen
dc.titleGenitourinary Rhabdomyosarcoma with Systemic Metastasis in a Young Dogen
dc.typeArticleen
dc.contributor.AlternativeAuthor김대용-
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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