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IL-1 beta Inhibits TGF beta in the Temporomandibular Joint

Cited 11 time in Web of Science Cited 11 time in Scopus
Authors
Lim, WH; Toothman, J; Miller, JH; Tallents, RH
Issue Date
2009-06
Publisher
American and International Associations for Dental
Citation
J Dent Res 88:557-562
Abstract
Similarly to humans, healthy, wild-type mice develop osteoarthritis, including of the temporomandibular joint (TMJ), as a result of aging. Pro-inflammatory cytokines, such as IL-1β, IL-6, and TNFα, are known to contribute to the development of osteoarthritis, whereas TGFβ has been associated with articular regeneration. We hypothesized that a balance between IL-1β and TGFβ underlies the development of TMJ osteoarthritis, whereby IL-1β signaling down-regulates TGFβ expression as part of disease pathology. Our studies in wild-type mice, as well as the Col1-IL1β XAT mouse model of osteoarthritis, demonstrated an inverse correlation between IL-1β and TGFβ expression in the TMJ. IL-1β etiologically correlated with joint pathology, whereas TGFβ expression associated with IL-1β down-regulation and improvement of articular pathology. Better understanding of the underlying inflammatory processes during disease will potentially enable us to harness inflammation for orofacial tissue regeneration. [PUBLICATION ABSTRACT]
ISSN
0022-0345
Language
English
URI
https://hdl.handle.net/10371/69789
DOI
https://doi.org/10.1177/0022034509336823
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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