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Interaction between the p75 neurotrophin receptor and a novel adaptor protein

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Issue Date
2008-06
Publisher
Korean Acadamy of Oral Biology
Citation
International Journal of Oral Biology. 33:71-76
Keywords
neurotrophinsp75 neurotrophin receptorneuronsignal transductionadaptor protein
Abstract
The neurotrophin plays an important role in the
development, differentiation and survival of the nervous
system in vertebrates. It exerts its cellular effects through
two different receptors, the Trk receptor tyrosine kinase
neurotrophin receptor and the p75 neurotrophin receptor, a
member of the tumor necrosis factor receptor superfamily.
Trk and p75 neurotrophin receptors utilize specific target
proteins to transmit signals into the cell. An ankyrin-rich
membrane spanning protein (ARMS) was identified as a
new p75 interacting protein and serves as a novel
downstream target of p75 neurotrophin receptor. We
sought to delineate the interaction between p75 and ARMS
by deletion constructs of p75 and green fluorescent protein
(GFP)-tagged ARMS. We examined the interaction
between these two proteins after overexpressing them in
HEK-293 cells. Using both Western blot analysis and
immunocytochemistry followed by confocal laser scanning
microscopy, we found out that the intracellular domain of
the p75 neurotrophin receptor was important for the
interaction with ARMS. The results from this study suggest
that ARMS may play an important role for mediating the
signals from p75 neurotrophin receptor into the cell.
ISSN
1226-7155
Language
Korean
URI
https://hdl.handle.net/10371/69796
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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