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Alpha-Lipoic Acid Inhibits Inflammatory Bone Resorption by Suppressing Prostaglandin E2 Synthesis.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ha, Hyunil | - |
dc.contributor.author | Lee, Jong-Ho | - |
dc.contributor.author | Kim, Ha-Neui | - |
dc.contributor.author | Kim, Hyun-Man | - |
dc.contributor.author | Kwak, Han Bok | - |
dc.contributor.author | Lee, Seungbok | - |
dc.contributor.author | Kim, Hong-Hee | - |
dc.contributor.author | Lee, Zang Hee | - |
dc.date.accessioned | 2010-09-12T23:42:37Z | - |
dc.date.available | 2010-09-12T23:42:37Z | - |
dc.date.issued | 2006-01 | - |
dc.identifier.citation | J. Immunol. 176:111-117 | en |
dc.identifier.issn | 0022-1767 (Print) | - |
dc.identifier.issn | 1550-6606 (Online) | - |
dc.identifier.uri | http://www.jimmunol.org/cgi/content/full/176/1/111 | - |
dc.identifier.uri | https://hdl.handle.net/10371/69801 | - |
dc.description.abstract | alpha-Lipoic acid (LA) has been intensely investigated as a therapeutic agent for several pathological conditions, including diabetic polyneuropathy. In the present study, we examined the effects of LA on osteoclastic bone loss associated with inflammation. LA significantly inhibited IL-1-induced osteoclast formation in cocultures of mouse osteoblasts and bone marrow cells, but LA had only a marginal effect on osteoclastogenesis from bone marrow macrophages induced by receptor activator of NF-kappaB ligand (RANKL). LA inhibited both the sustained up-regulation of RANKL expression and the production of PGE2 induced by IL-1 in osteoblasts. In addition, treatment with either prostaglandin E2 (PGE2) or RANKL rescued IL-1-induced osteoclast formation inhibited by LA or NS398, a specific cyclooxygenase-2 (COX-2) inhibitor, in cocultures. LA blocked IL-1-induced PGE2 production even in the presence of arachidonic acid, without affecting the expression of COX-2 and membrane-bound PGE2 synthase. Dihydrolipoic acid (the reduced form of LA), but not LA, attenuated recombinant COX-2 activity in vitro. LA also inhibited osteoclast formation and bone loss induced by IL-1 and LPS in mice. Our results suggest that the reduced form of LA inhibits COX-2 activity, PGE2 production, and sustained RANKL expression, thereby inhibiting osteoclast formation and bone loss in inflammatory conditions. | en |
dc.language.iso | en | en |
dc.publisher | American Association of Immunologists | en |
dc.title | Alpha-Lipoic Acid Inhibits Inflammatory Bone Resorption by Suppressing Prostaglandin E2 Synthesis. | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 하현일 | - |
dc.contributor.AlternativeAuthor | 이종호 | - |
dc.contributor.AlternativeAuthor | 김하늬 | - |
dc.contributor.AlternativeAuthor | 김현만 | - |
dc.contributor.AlternativeAuthor | 곽한복 | - |
dc.contributor.AlternativeAuthor | 이승복 | - |
dc.contributor.AlternativeAuthor | 김홍희 | - |
dc.contributor.AlternativeAuthor | 이장희 | - |
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